Inducible nitric oxide synthase and atherosclerosis

被引：15

作者：

Ikeda, U ^{[1
]}

Maeda, Y ^{[1
]}

Shimada, K ^{[1
]}

机构：

[1] Jichi Med Sch, Dept Cardiol, Minami Kawachi, Tochigi 32904, Japan

来源：

CLINICAL CARDIOLOGY | 1998年 / 21卷 / 07期

关键词：

nitric oxide; vascular smooth muscle; atherosclerosis; restenosis; gene transfer;

D O I：

10.1002/clc.4960210705

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nitric oxide (NO) synthase induction in vascular smooth muscle cells may play a role in local vascular injury associated with atherosclerosis or postangioplasty restenosis by inhibiting smooth muscle cell proliferation and contraction, as well as by preventing leukocyte and platelet adhesion. The expression of inducible NO synthase is increased in balloon-injured arteries of experimental animals or in human atherosclerotic lesions. Replacement therapy with NO donors or NO synthase gene transfer may improve the clinical course of atherosclerosis or restenosis.

引用

页码：473 / 476

页数：4

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