One-pot synthesis of tri- and tetra-substituted imidazoles using sodium dihydrogen phosphate under solvent-free conditions

被引：35

作者：

Karimi-Jaberi, Zahed ^{[1
]}

Barekat, Mohammad ^{[1
]}

机构：

[1] Islamic Azad Univ, Firoozabad Branch, Dept Chem, Firoozabad, Fars, Iran

来源：

CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 10期

关键词：

Sodium dihydrogen phosphate; Imidazoles; Benzil; Solvent-free; TETRASUBSTITUTED IMIDAZOLES; 1,2,4,5-TETRASUBSTITUTED IMIDAZOLES; HIGHLY EFFICIENT; INHIBITOR; CATALYST; ACID;

D O I：

10.1016/j.cclet.2010.06.012

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sodium dihydrogen phosphate (NaH2PO4) efficiently catalyzes the condensation reaction of benzil, aldehydes, amines and ammonium acetate in a four-component reaction under solvent-free conditions. The reaction proceeds rapidly and affords the corresponding tetra-substituted imidazoles in high yields. Also an efficient route was developed for the synthesis of tri-substituted imidazoles from condensation of benzil, aldehydes and ammonium acetate using NaH2PO4. (C) 2010 Zahed Karimi-Jaberi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：1183 / 1186

页数：4

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