One-pot synthesis of tri- and tetra-substituted imidazoles using sodium dihydrogen phosphate under solvent-free conditions

被引：33
|
作者：
Karimi-Jaberi, Zahed [1 ]
Barekat, Mohammad [1 ]
机构：
[1] Islamic Azad Univ, Firoozabad Branch, Dept Chem, Firoozabad, Fars, Iran
来源：
CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 10期
关键词：
Sodium dihydrogen phosphate; Imidazoles; Benzil; Solvent-free; TETRASUBSTITUTED IMIDAZOLES; 1,2,4,5-TETRASUBSTITUTED IMIDAZOLES; HIGHLY EFFICIENT; INHIBITOR; CATALYST; ACID;
D O I：
10.1016/j.cclet.2010.06.012
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sodium dihydrogen phosphate (NaH2PO4) efficiently catalyzes the condensation reaction of benzil, aldehydes, amines and ammonium acetate in a four-component reaction under solvent-free conditions. The reaction proceeds rapidly and affords the corresponding tetra-substituted imidazoles in high yields. Also an efficient route was developed for the synthesis of tri-substituted imidazoles from condensation of benzil, aldehydes and ammonium acetate using NaH2PO4. (C) 2010 Zahed Karimi-Jaberi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：1183 / 1186
页数：4
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