ATP release from the isolated perfused guinea pig heart in response to increased flow

被引：19
作者：
Vials, AJ
Burnstock, G
机构：
[1] UNIV LONDON UNIV COLL,DEPT ANAT & DEV BIOL,LONDON WC1E 6BT,ENGLAND
[2] UNIV LONDON UNIV COLL,CTR NEUROSCI,LONDON WC1E 6BT,ENGLAND
来源：
JOURNAL OF VASCULAR RESEARCH | 1996年 / 33卷 / 01期
关键词：
increased flow; ATP release; vascular resistance; guinea pig heart;
D O I：
10.1159/000159125
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The Langendorff heart preparation was used to investigate the release of ATP from the guinea pig heart in response to increased coronary flow. The luciferin-luciferase firefly technique was used to determine levels of ATP in the perfusate. During periods of increased flow, ATP release was rapidly and significantly increased by at least tenfold the basal release. The pressure/flow ratio was reduced in increased-flow conditions suggesting that coronary vasodilatation had occurred. It is concluded that ATP release from the guinea pig heart is increased under raised-flow conditions. It is suggested that this ATP release induces coronary vasodilatation.
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页码：1 / 4
页数：4
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