Oxidative Stress and Arterial Dysfunction in Peripheral Artery Disease

被引：63

作者：

Ismaeel, Ahmed ^{[1
]}

Brumberg, Robert S. ^{[2
]}

Kirk, Jeffrey S. ^{[3
]}

Papoutsi, Evlampia ^{[1
]}

Farmer, Patrick J. ^{[4
]}

Bohannon, William T. ^{[5
]}

Smith, Robert S. ^{[5
]}

Eidson, Jack L. ^{[5
]}

Sawicki, Ian ^{[5
]}

Koutakis, Panagiotis ^{[1
]}

机构：

[1] Florida State Univ, Dept Nutr Food & Exercise Sci, Tallahassee, FL 32304 USA

[2] Florida State Univ, Sch Med, Tallahassee Mem Hosp, Dept Surg,Vasc Surg Associates, Tallahassee, FL 32308 USA

[3] Capital Reg Med Ctr, Dept Surg, Tallahassee, FL 32308 USA

[4] Baylor Univ, Dept Chem & Biochem, Waco, TX 76798 USA

[5] Baylor Scott & White Med Ctr, Dept Surg, Temple, TX 76508 USA

来源：

ANTIOXIDANTS | 2018年 / 7卷 / 10期

关键词：

endothelial dysfunction; arterial stiffness; inflammation; NOX2; NO; C-REACTIVE PROTEIN; PROPIONYL-L-CARNITINE; AORTIC AUGMENTATION INDEX; EXHALED BREATH CONDENSATE; FLOW-MEDIATED DILATION; NITRIC-OXIDE SYNTHASE; ENDOTHELIAL DYSFUNCTION; ANGIOTENSIN-II; NADPH-OXIDASE; RISK-FACTORS;

D O I：

10.3390/antiox7100145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peripheral artery disease (PAD) is an atherosclerotic disease characterized by a narrowing of the arteries in the lower extremities. Disease manifestations are the result of more than just reduced blood flow, and include endothelial dysfunction, arterial stiffness, and inflammation. Growing evidence suggests that these factors lead to functional impairment and decline in PAD patients. Oxidative stress also plays an important role in the disease, and a growing amount of data suggest a link between arterial dysfunction and oxidative stress. In this review, we present the current evidence for the involvement of endothelial dysfunction, arterial stiffness, and inflammation in the pathophysiology of PAD. We also discuss the links between these factors and oxidative stress, with a focus on nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2)-derived reactive oxygen species (ROS) and decreased nitric oxide (NO) bioavailability. Finally, the potential therapeutic role of NOX2 antioxidants for improving arterial function and functional status in PAD patients is explored.

引用

页数：16

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