Pathophysiology of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: A Review

被引:201
作者
Dodd, William S. [1 ]
Laurent, Dimitri [1 ]
Dumont, Aaron S. [2 ]
Hasan, David M. [3 ]
Jabbour, Pascal M. [4 ]
Starke, Robert M. [5 ]
Hosaka, Koji [1 ]
Polifka, Adam J. [1 ]
Hoh, Brian L. [1 ]
Chalouhi, Nohra [1 ]
机构
[1] Univ Florida, Dept Neurosurg, Coll Med, Gainesville, FL 32610 USA
[2] Tulane Univ, Sch Med, Dept Neurol Surg, 1430 Tulane Ave, New Orleans, LA 70112 USA
[3] Univ Iowa, Carver Coll Med, Dept Neurosurg, Iowa City, IA USA
[4] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Neurol Surg, Philadelphia, PA 19107 USA
[5] Univ Miami, Dept Neurol Surg, Miller Sch Med, Coral Gables, FL 33124 USA
来源
JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2021年 / 10卷 / 15期
基金
美国国家卫生研究院;
关键词
delayed cerebral ischemia; intracranial aneurysm; stroke; subarachnoid hemorrhage; CORTICAL SPREADING DEPRESSION; NITRIC-OXIDE SYNTHASE; INTERCELLULAR-ADHESION MOLECULE-1; INTRAVENOUS HEPARIN INFUSION; DUAL ANTIPLATELET THERAPY; GRADE ANEURYSM PATIENTS; CASE-FATALITY RATES; EARLY BRAIN-INJURY; CEREBROSPINAL-FLUID; DOUBLE-BLIND;
D O I
10.1161/JAHA.121.021845
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many years of investigation and clinical trials. Modern advances in basic science have produced a much more complex, multifactorial framework in which delayed cerebral ischemia is better understood and novel treatments can be developed. Leveraging this knowledge to improve outcomes, however, depends on a holistic understanding of the disease process. We conducted a review of the literature to analyze the current state of investigation into delayed cerebral ischemia with emphasis on the major themes that have emerged over the past decades. Specifically, we discuss microcirculatory dysfunction, glymphatic impairment, inflammation, and neuroelectric disruption as pathological factors in addition to the canonical focus on cerebral vasospasm. This review intends to give clinicians and researchers a summary of the foundations of delayed cerebral ischemia pathophysiology while also underscoring the interactions and interdependencies between pathological factors. Through this overview, we also highlight the advances in translational studies and potential future therapeutic opportunities.
引用
收藏
页数:18
相关论文
共 222 条
[1]   Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage [J].
Ahn, Sung-Ho ;
Savarraj, Jude P. J. ;
Parsha, Kaushik ;
Hergenroeder, Georgene W. ;
Chang, Tiffany R. ;
Kim, Dong H. ;
Kitagawa, Ryan S. ;
Blackburn, Spiros L. ;
Choi, H. Alex .
JOURNAL OF NEUROINFLAMMATION, 2019, 16 (01)
[2]   Admission neutrophil-lymphocyte ratio predicts delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage [J].
Al-Mufti, Fawaz ;
Amuluru, Krishna ;
Damodara, Nitesh ;
Dodson, Vincent ;
Roh, David ;
Agarwal, Sachin ;
Meyers, Philip M. ;
Connolly, E. Sander ;
Schmidt, Michael J. ;
Claassen, Jan ;
Park, Soojin .
JOURNAL OF NEUROINTERVENTIONAL SURGERY, 2019, 11 (11) :1135-+
[3]   ENDOTHELIUM-DERIVED RELAXING FACTOR FROM CULTURED HUMAN-ENDOTHELIAL CELLS INHIBITS AGGREGATION OF HUMAN-PLATELETS [J].
ALHEID, U ;
FROLICH, JC ;
FORSTERMANN, U .
THROMBOSIS RESEARCH, 1987, 47 (05) :561-571
[4]   Antiplatelet and Anticoagulant Drugs in Interventional Radiology [J].
Altenburg, Alexander ;
Haage, Patrick .
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2012, 35 (01) :30-42
[5]   Lactate and Lactate Dehydrogenase in Cistern as Biomarkers of Early Brain Injury and Delayed Cerebral Ischemia of Subarachnoid Hemorrhage [J].
Anan, Mitsuhiro ;
Nagai, Yasuyuki ;
Fudaba, Hirotaka ;
Fujiki, Minoru .
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2020, 29 (05)
[6]   Endothelial influences on cerebrovascular tone [J].
Andresen, J ;
Shafi, NI ;
Bryan, RM .
JOURNAL OF APPLIED PHYSIOLOGY, 2006, 100 (01) :318-327
[7]   THE ROLE OF HEMOLYSATE IN THE FACILITATION OF OXYHEMOGLOBIN-INDUCED CONTRACTION IN RABBIT BASILAR ARTERIES [J].
AOKI, T ;
TAKENAKA, K ;
SUZUKI, S ;
KASSELL, NF ;
SAGHER, O ;
LEE, KS .
JOURNAL OF NEUROSURGERY, 1994, 81 (02) :261-266
[8]   Asymmetric and Symmetric Dimethylarginines are Markers of Delayed Cerebral Ischemia and Neurological Outcome in Patients with Subarachnoid Hemorrhage [J].
Appel, Daniel ;
Seeberger, Miriam ;
Schwedhelm, Edzard ;
Czorlich, Patrick ;
Goetz, Alwin E. ;
Boeger, Rainer H. ;
Hannemann, Juliane .
NEUROCRITICAL CARE, 2018, 29 (01) :84-93
[9]  
Armstead William M, 2016, Anesthesiol Clin, V34, P465, DOI 10.1016/j.anclin.2016.04.002
[10]   Suppression of cortical spreading depression in migraine prophylaxis [J].
Ayata, C ;
Jin, HW ;
Kudo, C ;
Dalkara, T ;
Moskowitz, MA .
ANNALS OF NEUROLOGY, 2006, 59 (04) :652-661