Estrogen-Related Receptors and the control of bone cell fate

被引：16
作者：
Carnesecchi, Julie [1 ,2 ]
Vanacker, Jean-Marc [1 ]
机构：
[1] Univ Lyon 1, Ecole Normale Super Lyon, Inst Genom Fonct Lyon, CNRS UMR5242, Lyon, France
[2] Heidelberg Univ, Dept Dev Biol, Ctr Organismal Studies, Bergheimer Str 58, D-69115 Heidelberg, Germany
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2016年 / 432卷 / 0C期
关键词：
Mesenchymal cells; Estrogen-Related Receptors; Bone cells; Bone loss; ALPHA ERR-ALPHA; INDEPENDENT TRANSCRIPTIONAL ACTIVATION; BREAST-CANCER CELLS; PHOSPHORYLATION-DEPENDENT SUMOYLATION; ORPHAN NUCLEAR RECEPTORS; FORMATION IN-VITRO; OSTEOBLAST DIFFERENTIATION; OSTEOPONTIN PROMOTER; THERAPEUTIC TARGET; BISPHENOL-A;
D O I：
10.1016/j.mce.2015.07.019
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Bone loss is naturally occurring in aging males and females and exacerbated in the latter after menopause, altogether leading to cumulative skeleton fragility and increased fracture risk. Two types of therapeutic strategies can be envisioned to counteract age- or menopause-associated bone loss, aiming at either reducing bone resorption exerted by osteoclasts or, alternatively, promoting bone formation by osteoblasts. We here summarize data suggesting that inhibition of the Estrogen-Related Receptors alpha and/or gamma could promote bone formation and compensate for bone loss induced by ageing or estrogen deficiency. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：47 / 53
页数：7
相关论文
共 110 条
[1]   ERRγ directs and maintains the transition to oxidative metabolism in the postnatal heart [J].
Alaynick, William A. ;
Kondo, Richard P. ;
Xie, Wen ;
He, Weimin ;
Dufour, Catherine R. ;
Downes, Michael ;
Jonker, Johan W. ;
Giles, Wayne ;
Naviaux, Robert K. ;
Giguere, Vincent ;
Evans, Ronald M. .
CELL METABOLISM, 2007, 6 (01) :13-24
[2]  
Ariazi EA, 2002, CANCER RES, V62, P6510
[3]   Estrogen-related receptor α regulates osteoblast differentiation via Wnt/β-catenin signaling [J].
Auld, Kathryn L. ;
Berasi, Stephen P. ;
Liu, Yan ;
Cain, Michael ;
Zhang, Ying ;
Huard, Christine ;
Fukayama, Shoichi ;
Zhang, Jing ;
Choe, Sung ;
Zhong, Wenyan ;
Bhat, Bheem M. ;
Bhat, Ramesh A. ;
Brown, Eugene L. ;
Martinez, Robert V. .
JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2012, 48 (02) :177-191
[4]   The ERRα orphan nuclear receptor controls morphogenetic movements during zebrafish gastrulation [J].
Bardet, PL ;
Horard, B ;
Laudet, V ;
Vanacker, JM .
DEVELOPMENTAL BIOLOGY, 2005, 281 (01) :102-111
[5]   Epiderma growth factor-induced signaling in breast cancer cells resufts in selective target gene activation by orphan nuclear receptor estrogen-related receptor α [J].
Barry, JB ;
Giguère, V .
CANCER RESEARCH, 2005, 65 (14) :6120-6129
[6]   ERRs and cancers: Effects on metabolism and on proliferation and migration capacities [J].
Bianco, Stephanie ;
Sailland, Juliette ;
Vanacker, Jean-Marc .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2012, 130 (3-5) :180-185
[7]   Modulating Estrogen Receptor-related Receptor-α Activity Inhibits Cell Proliferation [J].
Bianco, Stephanie ;
Lanvin, Olivia ;
Tribollet, Violaine ;
Macari, Claire ;
North, Sophie ;
Vanacker, Jean-Marc .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (35) :23286-23292
[8]   The orphan nuclear estrogen receptor-related receptor-α regulates cartilage formation in vitro:: Implication of Sox9 [J].
Bonnelye, E. ;
Zirngibl, R. A. ;
Jurdic, P. ;
Aubin, J. E. .
ENDOCRINOLOGY, 2007, 148 (03) :1195-1205
[9]   The ERR-1 orphan receptor is a transcriptional activator expressed during bone development [J].
Bonnelye, E ;
Vanacker, JM ;
Dittmar, T ;
Begue, A ;
Desbiens, X ;
Denhardt, DT ;
Aubin, JE ;
Laudet, V ;
Fournier, B .
MOLECULAR ENDOCRINOLOGY, 1997, 11 (07) :905-916
[10]   The orphan nuclear estrogen receptor-related receptor α (ERRα) is expressed throughout osteoblast differentiation and regulates bone formation in vitro [J].
Bonnelye, E ;
Merdad, L ;
Kung, V ;
Aubin, JE .
JOURNAL OF CELL BIOLOGY, 2001, 153 (05) :971-983
12345678910