Yeast: a microbe with macro-implications to antimicrobial drug discovery

被引：0

作者：

Balibar, Carl J. ^{[1
]}

Roemer, Terry ^{[2
]}

机构：

[1] Merck Res Labs, Involved Gram Negat Antibacterial Drug Discovery, Kenilworth, NJ USA

[2] Dept Infect Dis Research, Leading Early Antimicrobial Discovery, Merck, Kenilworth, NJ USA

来源：

BRIEFINGS IN FUNCTIONAL GENOMICS | 2016年 / 15卷 / 02期

关键词：

yeast; functional genomics; chemical biology; antifungal; antibacterial; Saccharomyces cerevisiae; BETA-LACTAM ANTIBIOTICS; SACCHAROMYCES-CEREVISIAE GENOME; ESSENTIAL GENE IDENTIFICATION; ESCHERICHIA-COLI; STAPHYLOCOCCUS-AUREUS; CANDIDA-ALBICANS; BIOLOGICAL-ACTIVITY; CHEMICAL GENOMICS; DELETION MUTANTS; ASPERGILLUS-FUMIGATUS;

D O I：

10.1093/bfgp/elv038

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Paramount to any rational discovery of new antibiotics displaying novel mechanisms of action is a deep knowledge of the genetic basis of microbial growth, division and virulence. The bakers' yeast, Saccharomyces cerevisiae, illustrates the highest understanding of the genetic underpinnings of microbial life, and from this framework, a systems biology paradigm has evolved, begging to be emulated in antibacterial discovery. Here, we review landmark events in the history of yeast genomics that provide this new foundation for antibacterial drug discovery.

引用

页码：147 / 154

页数：8

共 37 条

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