Vanillic acid mitigates the ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation

被引：47
作者：
Bai, Feng [1 ]
Fang, Liyun [2 ]
Hu, Huizhong [2 ]
Yang, Yang [2 ]
Feng, Xianxian [2 ]
Sun, Daqing [2 ]
机构：
[1] Northwest Women & Children Hosp, Dept Child Healthcare, Xian, Shaanxi, Peoples R China
[2] XiAn 3 Hosp, Dept Pediat, Xian, Shaanxi, Peoples R China
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2019年 / 83卷 / 03期
关键词：
Vanillic acid; ovalbumine; BALF; histology; inflammatory cytokines; INDUCED ALLERGIC-ASTHMA; MURINE MODEL; MODULATION; EXTRACT;
D O I：
10.1080/09168451.2018.1543015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Asthma is a chronic allergic ailment affecting a considerably large population of the world. The aim of this study is to evaluate the ameliorative effects of vanillic acid against ovalbumin (OVA)-induced asthma in rat model. Asthma was induced in Sprague Dawley rats and vanillic acid was orally administered at 25 and 50 mg/kg body weight for 28 days. Rats challenged with OVA showed heavy signs of airway inflammation and remodeling similar to chronic asthma, evidenced by the increased differential cell counts and presence of inflammatory cytokines in the bronchoalveolar lavage fluid (BALF), along with elevated serum immunoglobulin levels, and the histological results. However, vanillic acid dose-dependently attenuated the manifestation of OVA-induced asthma (p < 0.05) through suppression of inflammatory mediators and modulation of immunoglobulin levels in rats. The asthma mitigating properties of vanillic acid might be due to suppression of oxidative stress and prevention of lung airway inflammation.
引用
收藏
页码：531 / 537
页数：7
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