Come together, right...now: Synchronization of rhythms in a mammalian circadian clock

被引:213
作者
Aton, SJ [1 ]
Herzog, ED [1 ]
机构
[1] Washington Univ, Dept Biol, St Louis, MO 63130 USA
关键词
D O I
10.1016/j.neuron.2005.11.001
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In mammals, the suprachiasmatic nuclei (SCN) of the hypothalamus act as a dominant circadian pacemaker, coordinating rhythms throughout the body and regulating daily and seasonal changes in physiology and behavior. This review focuses on the mechanisms that mediate synchronization of circadian rhythms between SCN neurons. Understanding how these neurons communicate as a network of circadian oscillators has begun to shed light on the adaptability and dysfunction of the brain's master clock.
引用
收藏
页码:531 / 534
页数:4
相关论文
共 38 条
[1]   Circadian rhythms in isolated brain regions [J].
Abe, M ;
Herzog, ED ;
Yamazaki, S ;
Straume, M ;
Tei, H ;
Sakaki, Y ;
Menaker, M ;
Block, GD .
JOURNAL OF NEUROSCIENCE, 2002, 22 (01) :350-356
[2]   Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections [J].
Abrahamson, EE ;
Moore, RY .
BRAIN RESEARCH, 2001, 916 (1-2) :172-191
[3]   A GABAergic mechanism is necessary for coupling dissociable ventral and dorsal regional oscillators within the circadian clock [J].
Albus, H ;
Vansteensel, MJ ;
Michel, S ;
Block, GD ;
Meijer, JH .
CURRENT BIOLOGY, 2005, 15 (10) :886-893
[4]   Gates and oscillators: A network model of the brain clock [J].
Antle, MC ;
Foley, DK ;
Foley, NC ;
Silver, R .
JOURNAL OF BIOLOGICAL RHYTHMS, 2003, 18 (04) :339-350
[5]   Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons [J].
Aton, SJ ;
Colwell, CS ;
Harmar, AJ ;
Waschek, J ;
Herzog, ED .
NATURE NEUROSCIENCE, 2005, 8 (04) :476-483
[6]  
Colwell CS, 2000, J NEUROBIOL, V43, P379, DOI 10.1002/1097-4695(20000615)43:4<379::AID-NEU6>3.0.CO
[7]  
2-0
[8]   Disrupted circadian rhythms in VIP- and PHI-deficient mice [J].
Colwell, CS ;
Michel, S ;
Itri, J ;
Rodriguez, W ;
Tam, J ;
Lelievre, V ;
Hu, Z ;
Liu, X ;
Waschek, JA .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2003, 285 (05) :R939-R949
[9]   The mouse VPAC2 receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro [J].
Cutler, DJ ;
Haraura, M ;
Reed, HE ;
Shen, S ;
Sheward, WJ ;
Morrison, CF ;
Marston, HM ;
Harmar, AJ ;
Piggins, HD .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 17 (02) :197-204
[10]   Forced desynchronization of dual circadian oscillators within the rat suprachiasmatic nucleus [J].
de la Iglesia, HO ;
Cambras, T ;
Schwartz, WJ ;
Díez-Noguera, A .
CURRENT BIOLOGY, 2004, 14 (09) :796-800