Exploiting microRNAs for cell engineering and therapy

被引：25

作者：

Bratkovic, Tomaz ^{[1
]}

Glavan, Gordana ^{[2
]}

Strukelj, Borut ^{[1
]}

Zivin, Marko ^{[2
]}

Rogelj, Boris ^{[3
]}

机构：

[1] Univ Ljubljana, Fac Pharm, Dept Pharmaceut Biol, Ljubljana, Slovenia

[2] Univ Ljubljana, Fac Med, Inst Pathophysiol, Brain Res Lab, Ljubljana, Slovenia

[3] Jozef Stefan Inst, Dept Biotechnol, Ljubljana, Slovenia

来源：

BIOTECHNOLOGY ADVANCES | 2012年 / 30卷 / 03期

关键词：

MicroRNA; Biogenesis; Function; Cell engineering; Therapy; PLURIPOTENT STEM-CELLS; HEPATITIS-C VIRUS; SMALL RNAS; IN-VIVO; DIFFERENTIAL EXPRESSION; TRANSLATION INITIATION; HUMAN FIBROBLASTS; PROSTATE-CANCER; BINDING PROTEIN; GENE-EXPRESSION;

D O I：

10.1016/j.biotechadv.2012.01.006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

MicroRNAs (miRNAs) form a large class of non-coding RNAs that function in repression of gene expression in eukaryotes. By recognizing short stretches of nucleotides within the untranslated regions of mRNAs, miRNAs recruit partner proteins to individual transcripts, leading to mRNA cleavage or hindering of translation. Bioinformatic predictions and a wealth of data from wet laboratory studies indicate that miRNAs control expression of a large proportion of protein-coding genes, implying involvement of miRNAs in regulation of most biologic processes. In this review we discuss the biology of miRNAs and present examples of how manipulation of miRNA expression or activity can be exploited to attain the desired phenotypic traits in cell engineering as well as achieve therapeutic outcomes in treatment of a diverse set of diseases. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：753 / 765

页数：13

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