Substantia nigra hyperechogenicity assessed by transcranial sonography is related to neuropsychological impairment in the elderly population

被引：25

作者：

Liepelt, Inga ^{[1
]}

Wendt, Angela ^{[1
]}

Schweitzer, Katherine J. ^{[1
]}

Wolf, Bjoern ^{[1
]}

Godau, Jana ^{[1
]}

Gaenslen, Alexandra ^{[1
]}

Bruessel, Theresa ^{[1
]}

Berg, Daniela ^{[1
]}

机构：

[1] Univ Tubingen, Ctr Neurol, Dept Neurodegenerat, Hertie Inst Clin Brain Res, D-72076 Tubingen, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 2008年 / 115卷 / 07期

关键词：

transcranial ultrasound; neuropsychology; Parkinson's disease;

D O I：

10.1007/s00702-008-0043-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Transcranial sonography (TCS) is a valuable tool in the diagnosis of Parkinson's disease (PD). However, substantia nigra hyperechogenicity (SN+) in TCS has been shown to be also evident in about 8-10% of healthy persons. Neuroimaging studies and slight motor deficits in subjects with SN+ indicate functional impairment of the nigrostriatal system associated with the ultrasound sign. We questioned, whether SN+ may also be associated with neuropsychological deficits and whether there is a relation to other PD premotor markers. Thirty-six subjects with SN+ and 34 control persons (SN-) older than 50 years were investigated. The delayed verbal memory recall (LogII) of subjects with SN+ was significantly reduced compared to the performance of the control group (P = 0.02). Binary logistic regression analysis revealed that, besides UPDRS-III (P < 0.001) and positive family history for PD (P < 0.01), LogII (P < 0.05) seems to be independently associated with SN+.

引用

页码：993 / 999

页数：7

共 35 条

[1]

BAEUMLER G, 1985, FARB WORT INTERFEREN

[2] Substantia nigra echomorphology in the healthy very old: Correlation with motor slowing [J].