Micelles and nanoparticles for ultrasonic drug and gene delivery

被引:360
作者
Husseini, Ghaleb A. [1 ]
Pitt, William G. [2 ]
机构
[1] Amer Univ Sharjah, Dept Chem Engn, Sharjah, U Arab Emirates
[2] Brigham Young Univ, Dept Chem Engn, Provo, UT 84602 USA
关键词
targeted delivery; polymeric micelles; thermo-responsive polymers; ultrasound; non-viral gene transfection; drug delivery; nanoemulsions; solid nanoparticles; liposomes;
D O I
10.1016/j.addr.2008.03.008
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Drug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues selectively, thus reducing the agent's side effects on the rest of the body. Ultrasound, traditionally used in diagnostic medicine, is finding a place in drug delivery in connection with these nanoparticles. In addition to their non-invasive nature and the fact that they can be focused on targeted tissues, acoustic waves have been credited with releasing pharmacological agents from nanocarriers, as well as rendering cell membranes more permeable. In this article, we summarize new technologies that combine the use of nanoparticles with acoustic power both in drug and gene delivery. Ultrasonic drug delivery from micelles usually employs polyether block copolymers and has been found effective in vivo for treating tumors. Ultrasound releases drug from micelles, most probably via shear stress and shock waves from the collapse of cavitation bubbles. Liquid emulsions and solid nanoparticles are used with ultrasound to deliver genes in vitro and in vivo. The small packaging allows nanoparticles to extravasate into tumor tissues. Ultrasonic drug and gene delivery from nanocarriers has tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly non-invasive means. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:1137 / 1152
页数:16
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