Snaring the function of α-synuclein

被引：138

作者：

Bonini, NM ^{[1
]}

Glasson, BI

机构：

[1] Univ Penn, Sch Med, Dept Biol, Philadelphia, PA 19104 USA

[2] Univ Penn, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA

来源：

CELL | 2005年 / 123卷 / 03期

关键词：

D O I：

10.1016/j.cell.2005.10.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is well established that the abundant neuronal protein a-synuclein has a causal role in Parkinson's disease, yet the normal functions of this protein remain unclear. In this issue of Cell, Chandra et al. (2005) reveal that a-synuclein acts as a molecular chaperone, assisting in the folding and refolding of synaptic proteins called SNAREs. These proteins are crucial for release of neurotransmitters at the neuronal synapse, vesicle recycling, and synaptic integrity.

引用

页码：359 / 361

页数：3

共 10 条

[1] Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease [J].

Auluck, PK ;

Chan, HYE ;

Trojanowski, JQ ;

Lee, VMY ;

Bonini, NM .

SCIENCE, 2002, 295 (5556) :865-868

[2] The DnaJ-like cysteine string protein and exocytotic neurotransmitter release [J].

Buchner, E ;

Gundersen, CB .

TRENDS IN NEUROSCIENCES, 1997, 20 (05) :223-227

[3] α-synuclein cooperates with CSPα in preventing neurodegeneration [J].

Chandra, S ;

Gallardo, G ;

Fernández-Chacón, R ;

Schlüter, OM ;

Südhof, TC .

CELL, 2005, 123 (03) :383-396

[4] Double-knockout mice for α- and β-synucleins:: Effect on synaptic functions [J].

Chandra, S ;

Fornai, F ;

Kwon, HB ;

Yazdani, U ;

Atasoy, D ;

Liu, XR ;

Hammer, RE ;

Battaglia, G ;

German, DC ;

Castillo, PE ;

Südhof, TC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (41) :14966-14971

[5] The biochemistry of Parkinson's disease [J].

Cookson, MR .

ANNUAL REVIEW OF BIOCHEMISTRY, 2005, 74 :29-52

[6] Molecular pathways of neurodegeneration in Parkinson's disease [J].

Dawson, TM ;

Dawson, VL .

SCIENCE, 2003, 302 (5646) :819-822

[7] The synaptic vesicle protein CSPα prevents presynaptic degeneration [J].

Fernández-Chacón, R ;

Wölfel, M ;

Nishimune, H ;

Tabares, L ;

Schmitz, F ;

Castellano-Muñoz, M ;

Rosenmund, C ;

Montesinos, ML ;

Sanes, JR ;

Schneggenburger, R ;

Südhof, TC .

NEURON, 2004, 42 (02) :237-251

[8] Are ubiquitination pathways central to Parkinson's disease? [J].

Giasson, BI ;

Lee, VMY .

CELL, 2003, 114 (01) :1-8

[9] A trimeric protein complex functions as a synaptic chaperone machine [J].

Tobaben, S ;

Thakur, P ;

Fernández-Chacón, R ;

Südhof, TC ;

Rettig, J ;

Stahl, B .

NEURON, 2001, 31 (06) :987-999

[10] SNARE protein structure and function [J].

Ungar, D ;

Hughson, FM .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2003, 19 :493-517

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