A systematic review comparing sex differences in cognitive function in schizophrenia and in rodent models for schizophrenia, implications for improved therapeutic strategies

被引:65
作者
Leger, Marianne [1 ]
Neill, Joanna C. [2 ]
机构
[1] Univ Caen Normandie, Normandie Univ, GMPc, EA 4259, F-14032 Caen, France
[2] Univ Manchester, Manchester Pharm Sch, Manchester M13 9PT, Lancs, England
关键词
Gender or sex differences; Schizophrenia; Cognition; Working and short-term memory; Visual learning and memory; Attention; Speed of processing; Reasoning and problem solving; Social cognition; Human; Mice; Rats; CONTINUOUS PERFORMANCE-TEST; NEURODEVELOPMENTAL RAT MODEL; FACIAL EMOTION RECOGNITION; MEDIAL PREFRONTAL CORTEX; HIPPOCAMPAL LESION MODEL; IDENTICAL PAIRS VERSION; GENDER-DIFFERENCES; SOCIAL-INTERACTION; ANIMAL-MODEL; NEGATIVE SYMPTOMS;
D O I
10.1016/j.neubiorev.2016.06.029
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Sex is often overlooked in animal and human research. Cognitive impairment associated with schizophrenia (CIAS) remains an unmet clinical need, as current antipsychotic medication does not provide clinically meaningful improvements. One explanation could be lack of appreciation of gender differences in CIAS. Animal models play a critical role in drug development and improved translation to the clinic is an on-going process. Our systematic review aims to evaluate how well the animal studies translate into clinical findings. Supporting clinical results, our review highlights a male working memory advantage and a female advantage for visual memory and social cognition in rodent models for schizophrenia. Not investigated in animals, a female advantage for attention and speed of processing has been found in schizophrenia patients. Sex differences in reasoning and problem solving are poorly investigated in both human and animal studies. Overall, our review provides evidence of good translation from the animal models into the clinic when sexual dimorphism is assessed. Enhanced understanding of these sex differences will improve the management of CIAS. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:979 / 1000
页数:22
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