Pros of priming in the diagnosis of growth hormone deficiency

被引:4
作者
Gonc, E. Nazli [1 ]
Ozon, Alev [1 ]
Alikasifoglu, Ayfer [1 ]
Kandemir, Nurgun [1 ]
机构
[1] Hacettepe Univ, Fac Med, Dept Pediat Endocrinol, TR-06100 Ankara, Turkey
关键词
final height; growth hormone; growth hormone deficiency; growth hormone stimulation tests; priming; sex steroids; GH DEFICIENCY; DELAYED PUBERTY; PROVOCATIVE TESTS; SHORT CHILDREN; SHORT STATURE; FINAL HEIGHT; SECRETION; BOYS; TESTOSTERONE; REEVALUATION;
D O I
10.1515/JPEM.2011.076
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Priming with sex steroids in stimulation tests for the diagnosis of GHD is still under debate. Most of the data on utility of priming during GH stimulation so far seem to support its use in the diagnosis of GHD in childhood. There is a propensity to treat growth retarded children who test subnormally to stimulation tests with GH. However, some studies analyzing the final height or height gain during GH treatment in such children failed to show any improvement in height. This paper summarizes previous studies on priming to analyze the utility of priming as a valid method to better the diagnostic capacity of the test.
引用
收藏
页码:9 / 11
页数:3
相关论文
共 23 条
[11]  
Illig R., 1983, EVALUATION GROWTH HO, P75
[12]  
Israel E, 2000, J CLIN ENDOCR METAB, V85, P3990
[13]   Results of early reevaluation of growth hormone secretion in short children with apparent growth hormone deficiency [J].
Loche, S ;
Bizzarri, C ;
Maghnie, M ;
Faedda, A ;
Tzialla, C ;
Autelli, M ;
Casini, MR ;
Cappa, M .
JOURNAL OF PEDIATRICS, 2002, 140 (04) :445-449
[14]  
Longas AF, 1996, J PEDIATR ENDOCR MET, V9, P345
[15]   THE EFFECTS OF ESTROGEN PRIMING AND PUBERTY ON THE GROWTH-HORMONE RESPONSE TO STANDARDIZED TREADMILL EXERCISE AND ARGININE-INSULIN IN NORMAL GIRLS AND BOYS [J].
MARIN, G ;
DOMENE, HM ;
BARNES, KM ;
BLACKWELL, BJ ;
CASSORLA, FG ;
CUTLER, GB .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 79 (02) :537-541
[16]   Estrogen priming effect on growth hormone (GH) provocative test:: A useful tool for the diagnosis of GH deficiency [J].
Martínez, AS ;
Domené, HM ;
Ropelato, MG ;
Jasper, HG ;
Pennisi, PA ;
Escobar, ME ;
Heinrich, JJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (11) :4168-4172
[17]   AUGMENTATION OF GROWTH-HORMONE SECRETION DURING PUBERTY - EVIDENCE FOR A PULSE AMPLITUDE-MODULATED PHENOMENON [J].
MAURAS, N ;
BLIZZARD, RM ;
LINK, K ;
JOHNSON, ML ;
ROGOL, AD ;
VELDHUIS, JD .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 64 (03) :596-601
[18]  
Molina S, 2008, J PEDIATR ENDOCR MET, V21, P257
[19]  
Müller G, 2004, J PEDIATR ENDOCR MET, V17, P77
[20]   Effect of growth hormone (GH) treatment on the near-final height of 1258 patients with idiopathic GH deficiency: Analysis of a large international database [J].
Reiter, Edward O. ;
Price, David A. ;
Wilton, Patrick ;
Albertsson-Wikland, Kerstin ;
Ranke, Michael B. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (06) :2047-2054