Pros of priming in the diagnosis of growth hormone deficiency

被引：4

作者：

Gonc, E. Nazli ^{[1
]}

Ozon, Alev ^{[1
]}

Alikasifoglu, Ayfer ^{[1
]}

Kandemir, Nurgun ^{[1
]}

机构：

[1] Hacettepe Univ, Fac Med, Dept Pediat Endocrinol, TR-06100 Ankara, Turkey

来源：

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2011年 / 24卷 / 1-2期

关键词：

final height; growth hormone; growth hormone deficiency; growth hormone stimulation tests; priming; sex steroids; GH DEFICIENCY; DELAYED PUBERTY; PROVOCATIVE TESTS; SHORT CHILDREN; SHORT STATURE; FINAL HEIGHT; SECRETION; BOYS; TESTOSTERONE; REEVALUATION;

D O I：

10.1515/JPEM.2011.076

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Priming with sex steroids in stimulation tests for the diagnosis of GHD is still under debate. Most of the data on utility of priming during GH stimulation so far seem to support its use in the diagnosis of GHD in childhood. There is a propensity to treat growth retarded children who test subnormally to stimulation tests with GH. However, some studies analyzing the final height or height gain during GH treatment in such children failed to show any improvement in height. This paper summarizes previous studies on priming to analyze the utility of priming as a valid method to better the diagnostic capacity of the test.

引用

页码：9 / 11

页数：3

共 23 条

[1] MANAGEMENT OF THE SHORT STATURE DUE TO PUBERTAL DELAY IN BOYS [J].

ADAN, L ;

SOUBERBIELLE, JC ;

BRAUNER, R .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 78 (02) :478-482

[2] VALUE AND LIMITS OF PHARMACOLOGICAL AND PHYSIOLOGICAL TESTS TO DIAGNOSE GROWTH-HORMONE (GH) DEFICIENCY AND PREDICT THERAPY RESPONSE - FIRST AND 2ND RETESTING DURING REPLACEMENT THERAPY OF PATIENTS DEFINED AS GH DEFICIENT [J].

CACCIARI, E ;

TASSONI, P ;

CICOGNANI, A ;

PIRAZZOLI, P ;

SALARDI, S ;

BALSAMO, A ;

CASSIO, A ;

ZUCCHINI, S ;

COLLI, C ;

TASSINARI, D ;

TANI, G ;

GUALANDI, S .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 79 (06) :1663-1669

[3]

Couto-Silva AC, 2005, J PEDIATR ENDOCR MET, V18, P807

[4]

Darendeliler F, 2004, J PEDIATR ENDOCR MET, V17, P1007

[5]

den Broeck JV, 1999, HORM RES, V51, P1

[6]

Gonc EN, 2008, J PEDIATR ENDOCR MET, V21, P963

[7] Comparison of stimulated growth hormone levels in primed versus unprimed provocative tests -: Effect of various testosterone doses on growth hormone levels [J].

Gönç, EN ;

Yordam, N ;

Kandemir, N ;

Alikasifoglu, A .

HORMONE RESEARCH, 2001, 56 (1-2) :32-37

[8] TRANSIENT PARTIAL HGH DEFICIENCY IN PREPUBERTAL CHILDREN WITH DELAY OF GROWTH [J].

GOURMELEN, M ;

PHAMHUUTRUNG, MT ;

GIRARD, F .

PEDIATRIC RESEARCH, 1979, 13 (04) :221-224

[9] TEST OF GROWTH-HORMONE SECRETION IN ADULTS - POOR REPRODUCIBILITY OF THE INSULIN TOLERANCE-TEST [J].

HOECK, HC ;

VESTERGAARD, P ;

JAKOBSEN, PE ;

LAURBERG, P .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1995, 133 (03) :305-312

[10] EFFECT OF TESTOSTERONE ON GROWTH HORMONE SECRETION IN PATIENTS WITH ANORCHIA AND DELAYED PUBERTY [J].

ILLIG, R ;

PRADER, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1970, 30 (05) :615-+

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