Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: The Cache County Study

被引：51

作者：

Fotuhi, Majid ^{[1
,2
]}

Zandi, Peter P. ^{[3
]}

Hayden, Kathleen M. ^{[4
]}

Khachaturian, Ara S. ^{[5
]}

Szekely, Christine A. ^{[3
]}

Wengreen, Heidi ^{[6
]}

Munger, Ronald G. ^{[6
]}

Norton, Maria C. ^{[7
,8
]}

Tschanz, JoAnn T. ^{[7
,8
]}

Lyketsos, Constantine G. ^{[9
,10
]}

Breitner, John C. S. ^{[11
]}

Welsh-Bohmer, Kathleen ^{[4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[2] LifeBridge Hlth Brain & Spine Inst, Ctr Memory & Brain Hlth, Baltimore, MD USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA

[4] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA

[5] Khachaturian & Associates Inc, Potomac, MD USA

[6] Utah State Univ, Dept Nutr & Food Sci, Logan, UT 84322 USA

[7] Utah State Univ, Dept Psychol, Logan, UT 84322 USA

[8] Utah State Univ, Ctr Epidemiol Studies, Logan, UT 84322 USA

[9] Dept Psychiat, Baltimore, MD USA

[10] Div Geriatr Psychiat & Neuropsychiat, Baltimore, MD USA

[11] Univ Washington, Dept Psychiat, VA Puget Sound Hlth Care Syst, Seattle, WA 98195 USA

来源：

ALZHEIMERS & DEMENTIA | 2008年 / 4卷 / 03期

关键词：

antioxidant vitamins; NSAIDs; cognitive performance; random effect model; dementia prevention;

D O I：

10.1016/j.jalz.2008.01.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Studies have shown less cognitive decline and lower risk of Alzheimer's disease in elderly individuals consuming either antioxidant vitamins or nonsteroidall anti-inflammatory drugs (NSAIDs). The potential of added benefit from their combined use has not been studied. We therefore analyzed data from 3,376 elderly participants of the Cache County Study who were given the Modified Mini-Mental State examination up to three times during a period of 8 years. Those who used a combination of vitamins E and C supplements and NSAIDs at baseline declined by an average 0.96 fewer points every 3 years than nonusers (P <.05). This apparent effect was attributable entirely to participants with the APOE epsilon 4 allele, whose users declined by 2.25 fewer points than nonusers every 3 years (P <.05). These results suggest that among elderly individuals with an APOE epsilon 4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time. (C) 2008 The Alzheimer's Association. All rights reserved .

引用

页码：223 / 227

页数：5

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