Surface Cross-Linked Poly (Vinyl Alcohol) Hydrogel for Colon Targeted Drug Release

被引：16

作者：

Basak, Piyali ^{[1
]}

Adhikari, Basudam ^{[2
]}

Sen, Alok Kumar ^{[2
]}

机构：

[1] Jadavpur Univ, Sch Biosci & Engn, Kolkata 700032, India

[2] Indian Inst Technol, Ctr Mat Sci, Kharagpur 721302, W Bengal, India

来源：

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING | 2011年 / 50卷 / 13期

关键词：

Burst release; Colon targeted; Drug delivery; Hydrogel; SGF; Surface cross-linking; DELIVERY SYSTEM; INITIAL BURST; LINKING; TABLET;

D O I：

10.1080/03602559.2011.584238

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A series of surface cross-linked PVA hydrogels (previously bulk cross-linked with maleic anhydride) were prepared for different cross-linker (glutaraldehyde) concentration. FTIR-ATR study revealed the cross-linking reaction. Surface cross-linking results in contraction of pores and increase in hydrophobicity, pore tortuosity around the surface of the membrane. As a result swelling, drug release decreases with increasing glutaraldehyde concentration. After surface cross-linking swelling of the hydrogels in simulated gastric fluid (SGF) further decreased to attain half of the value as observed for only bulk cross-linked membranes. Surface cross-linking has improved the colon-targeted release characteristics of the drugs from the PVA hydrogels.

引用

页码：1357 / 1361

页数：5

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