L-Proline catalyzed one-pot synthesis of polysubstituted pyridine system incorporating benzothiazole moiety via sustainable sonochemical approach

被引：17

作者：

Ibrahim, Hamada Mohamed ^{[1
]}

Arafa, Wael Abdelgayed Ahmed ^{[1
,2
]}

Behbehani, Haider ^{[3
]}

机构：

[1] Fayoum Univ, Chem Dept, Fac Sci, POB 63514, Al Fayyum, Egypt

[2] Jouf Univ, Coll Sci, Chem Dept, POB 2014, Sakaka, Aljouf, Saudi Arabia

[3] Kuwait Univ, Fac Sci, Chem Dept, POB 5969, Safat 13060, Kuwait

来源：

RSC ADVANCES | 2018年 / 8卷 / 66期

关键词：

MICHAEL ADDITION; 4+1 CYCLOADDITION; IN-VITRO; DERIVATIVES; SERIES; HETEROCYCLES; THIAZOLE; STRATEGY; UTILITY;

D O I：

10.1039/c8ra07013j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The efficient, highly convenient synthesis of polysubstituted pyridine derivatives was established via the reaction of N-(benzothiazol-2-yl)-2-cyanoacetamides with an assortment of arylidene malononitriles and arylidene ethyl cyanoacetates in the presence of l-proline as an efficient organocatalyst for this type of ultrasonic-mediated Michael addition. The mechanistic pathway and factors affecting this reaction were also established. The main characteristics of this procedure are high yields, use of a cost-effective catalyst, and easy work-up and purification.

引用

页码：37606 / 37617

页数：12

共 63 条

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