ANTI-ALZHEIMER ACTIVITY OF SUBSTANCES FROM NATURAL PRODUCTS AND OF SYNTHETIC ORIGIN: SOME IMPORTANT EXAMPLES OF THE LAST 20 YEARS.

被引：1

作者：

Silva Vellosa, Ana Beatriz ^{[1
]}

Lima Filho, Valdinei Bueno ^{[2
]}

Soares, Breno Almeida ^{[2
]}

Nascimento-Junior, Nailton ^{[1
]}

机构：

[1] Univ Estadual Paulista, Inst Quim, Dept Bioquim & Quim Organ, Lab Quim Med Sintese Organ & Modelagem Mol LaQMed, BR-14800060 Araraquara, SP, Brazil

[2] Univ Fed Jatai, Unidade Acad Ciencias Exatas & Tecnol, Campus Jatoba, BR-75801615 Jatai, GO, Brazil

来源：

QUIMICA NOVA | 2022年 / 45卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

AChE inhibitors; BuChE inhibitors; Alzheimer's disease; bioactive natural products; synthetic derivatives; BIOLOGICAL EVALUATION; HUMAN ACETYLCHOLINESTERASE; POTENTIAL TREATMENT; CRYSTAL-STRUCTURE; HIGHLY POTENT; IN-SILICO; DISEASE; DESIGN; DERIVATIVES; INHIBITORS;

D O I：

10.21577/0100-4042.20170860

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Alzheimer's disease has about 9.9 million new cases annually, according to World Health Organization. Due to the increasing incidence of people affected by AD and the absence of an efficient treatment or cure so far, many researchers worldwide are involved in the search for novel promising drugs candidates, through several targets, exploring distinct structural patterns. In this context, we describe herein, focusing the last 20 years, strategic examples of substances with targets related to Alzheimer's disease derived from natural products, such as alkaloids, chalcones, coumarins and flavonoids, in addition to carbamates and heterocyclic compounds. Furthermore, some cases are discussed where computational chemistry is used to better understand protein-ligand interactions.

引用

页码：435 / 454

页数：20

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