Enzyme-activated intracellular drug delivery with tubule clay nanoformulation

被引：148
作者：
Dzamukova, Maria R. [1 ]
Naumenko, Ekaterina A. [1 ]
Lvov, Yuri M. [2 ]
Fakhrullin, Rawil F. [1 ,2 ]
机构：
[1] Kazan Fed Univ, Inst Fundamental Med & Biol, Bionanotechnol Lab, Kazan 420008, Republic Of Tat, Russia
[2] Louisiana Tech Univ, Inst Micromfg, Ruston, LA 71272 USA
来源：
SCIENTIFIC REPORTS | 2015年 / 5卷
关键词：
MESOPOROUS SILICA NANOPARTICLES; SUSTAINED-RELEASE; NANOCARRIERS; DOXORUBICIN; TOXICITY;
D O I：
10.1038/srep10560
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Fabrication of stimuli-triggered drug delivery vehicle s is an important milestone in treating cancer. Here we demonstrate the selective anticancer drug delivery into human cells with biocompatible 50-nm diameter halloysite nanotube carriers. Physically-adsorbed dextrin end stoppers secure the intercellular release of brilliant green. Drug-loaded nanotubes penetrate through the cellular membranes and their uptake efficiency depends on the cells growth rate. Intercellular glycosyl hydrolases-mediated decomposition of the dextrin tube-end stoppers triggers the release of the lumen-loaded brilliant green, which allowed for preferable elimination of human lung carcinoma cells (A549) as compared with hepatoma cells (Hep3b). The enzyme-activated intracellular delivery of brilliant green using dextrin-coated halloysite nanotubes is a promising platform for anticancer treatment.
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页数：11
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