Preeclampsia - Recent insights

被引：527
作者：
Roberts, JM
Gammill, HS
机构：
[1] Magee Womens Res Inst, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA
[3] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA USA
来源：
HYPERTENSION | 2005年 / 46卷 / 06期
关键词：
preeclampsia; hypertension; pregnancy; oxidative stress; endothelium;
D O I：
10.1161/01.HYP.0000188408.49896.c5
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Preeclampsia is a pregnancy complication with serious consequences for mother and infant. The disorder is diagnosed by gestational hypertension and proteinuria but is far more than pregnancy induced hypertension. Preeclampsia is proposed to occur in 2 stages. Stage 1 reduced placental perfusion is postulated as the root cause and to lead to the maternal syndrome, Stage 2. Why perfusion is reduced, how this translates to a maternal disease in some but not all women and what is the linkage of the 2 stages are topics of intense study. In the last decade such studies have provided valuable insights into pathophysiology that now guide ongoing clinical trials.
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收藏
页码：1243 / 1249
页数：7
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