Rapid signaling of steroid hormones in the vertebrate nervous system

被引：22

作者：

Sakamoto, Hirotaka ^{[1
]}

Takahashi, Hideya ^{[2
]}

Matsuda, Ken-Ichi ^{[3
]}

Nishi, Mayumi ^{[4
]}

Takanami, Keiko ^{[3
]}

Ogoshi, Maho ^{[1
]}

Sakamoto, Tatsuya ^{[1
]}

Kawata, Mitsuhiro ^{[3
]}

机构：

[1] Okayama Univ, Ushimado Marine Lab, Grad Sch Nat Sci & Technol, Okayama 7014303, Japan

[2] Niigata Univ, Fac Sci, Dept Environm Sci, Niigata 9502181, Japan

[3] Kyoto Prefectural Univ Med, Dept Anat & Neurobiol, Kamigyo Ku, Kyoto 6028566, Japan

[4] Nara Med Univ, Dept Anat & Cell Biol, Kashihara, Nara 6348521, Japan

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2012年 / 17卷

关键词：

Behavior; Central nervous system; Neuroendocrinology; Non-genomic actions; Steroid hormones; Vertebrates; Review; PROGESTERONE-BINDING-PROTEIN; MEMBRANE ESTROGEN-RECEPTOR; DEVELOPING PURKINJE-CELL; INNER ZONE ANTIGEN; MULTIPLE CORTICOSTEROID RECEPTORS; DEVELOPING NEUROMUSCULAR SYSTEM; NUCLEUS-TRACTUS-SOLITARIUS; OVARIECTOMIZED WISTAR RATS; ROOT GANGLION NEURONS; SYNTHESIZED DE-NOVO;

D O I：

10.2741/3970

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Steroid hormones easily cross the blood-brain barrier because of their physicochemical lipid solubility. The hormones act through nuclear receptor-mediated mechanisms and modulate gene transcription. In contrast to their genomic actions, the non-genomic rapid action of steroid hormones, acting via various types of membrane-associated receptors, reveals pharmacological properties that are distinct from the actions of the intracellular nuclear receptors. As a result, non-genomic rapid actions have gained increased scientific interest. However, insight into the phylogenic and/or comparative actions of steroids in the brain is still poorly understood. In this review, we summarize recent findings concerning the rapid, non-genomic signaling of steroid hormones in the vertebrate central nervous system, and we discuss (using a comparative view from fish to mammals) recently published data regarding the mechanism underlying physiology and behavior.

引用

页码：996 / 1019

页数：24

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