Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

被引：295
作者：
Franke, Andre [1 ]
Balschun, Tobias [1 ]
Karlsen, Tom H. [2 ]
Hedderich, Juergen [3 ]
May, Sandra [1 ]
Lu, Tim [3 ]
Schuldt, Doerthe [1 ,4 ]
Nikolaus, Susanna [4 ]
Rosenstiel, Philip [1 ]
Krawczak, Michael [3 ]
Schreiber, Stefan [1 ,4 ]
机构：
[1] Univ Kiel, Inst Clin Mol Biol, D-24105 Kiel, Germany
[2] Univ Oslo, Rikshosp, Univ Hosp, Dept Med, N-0027 Oslo, Norway
[3] Univ Kiel, Inst Med Informat & Stat, D-24105 Kiel, Germany
[4] Univ Kiel, Dept Gen Internal Med, Univ Hosp Schleswig Holstein, D-24105 Kiel, Germany
来源：
NATURE GENETICS | 2008年 / 40卷 / 06期
关键词：
D O I：
10.1038/ng.148
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.
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收藏
页码：713 / 715
页数：3
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