Palladium-catalyzed cross-coupling of stereospecific potassium cyclopropyl trifluoroborates with aryl bromides

被引：81

作者：

Fang, GH ^{[1
]}

Yan, ZJ ^{[1
]}

Deng, MZ ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 03期

关键词：

D O I：

10.1021/ol036184e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereospecific cyclopropanation of alkenylboronic esters of pinacol followed by in situ treatment with excess KHF2 afforded the corresponding potassium cyclopropyl trifluoroborates in high yields, which then underwent Suzuki-Miyaura cross-coupling reactions with aryl bromides to give cyclopropyl-substituted arenes in good yields with retention of configuration. This promises to be a useful method for the synthesis of enantiomerically pure cyclopropanes.

引用

页码：357 / 360

页数：4

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