Effect of mate tea (Ilex paraguariensis) supplementation on oxidative stress biomarkers and LDL oxidisability in normo- and hyperlipidaemic humans

被引：28
作者：
Arcari, Demetrius Paiva [1 ]
Porto, Viviane Bozolan [2 ]
Varalda Rodrigues, Elis Regina [1 ]
Martins, Fernanda [2 ]
de Lima, Rosemary Joana [2 ]
Helena Frankland Sawaya, Alexandra Christine [3 ]
Ribeiro, Marcelo Lima [1 ]
Carvalho, Patricia de Oliveira [2 ]
机构：
[1] Univ Sao Francisco, Unidade Integrada Farmacol & Gastroenterol, BR-12900000 Braganca Paulista, SP, Brazil
[2] Univ Sao Francisco, Lab Multidisciplinar Pesquisa, BR-12900000 Braganca Paulista, SP, Brazil
[3] State Univ Campinas UNICAMP, Inst Biol, Dept Plant Biol, BR-13083970 Campinas, SP, Brazil
来源：
JOURNAL OF FUNCTIONAL FOODS | 2011年 / 3卷 / 03期
关键词：
Ilex paraguariensis; Oxidative stress; LDL oxidisability; Lipid peroxidation and biochemical parameters; DENSITY-LIPOPROTEIN OXIDATION; DNA-DAMAGE; LIPID-PEROXIDATION; ANTIOXIDANT ACTIVITY; STRAND BREAKS; IN-VIVO; ATHEROSCLEROSIS; EXTRACTS; POLYPHENOLS; HYPOTHESIS;
D O I：
10.1016/j.jff.2011.04.001
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The effects of mate tea (MT) supplementation on LDL oxidisability and oxidative stress biomarkers in normolipidaemic and hyperlipidaemic volunteers after 60 days of ingestion were investigated. A total of 60 volunteers, of whom 18 were hyperlipidaemic and 42 were normolipidaemic, ingested 200 ml of MT (12.5 mg/ml) per day. The oxidative stress was evaluated by means of comet assay analysis, serum total antioxidant status (TAS), lipid peroxidation products evaluated by thiobarbituric acid reactive substances (TBARS) in serum, enzymatic activity of the erythrocytes Cu-Zn superoxide dismutase (Cu-Zn SOD) and glutathione peroxidase (GSH-Px), and susceptibility to copper-induced in vitro oxidation of LDL was monitored by diene conjugates. It was observed that hyperlipidaemia caused an increase in lipid peroxidation products (P < 0.001), which significantly decreased after mate tea ingestion. The serum TAS level and SOD activity were significantly increased for both groups after supplementation with MT. In addition, the susceptibility of LDL to oxidation and H2O2-induced DNA breakage after supplementation of MT for normo- and hyperlipidaemic volunteers was found to have decreased. These results show that regular ingestion of MT may improve the antioxidant capacity of body and the resistance of LDL particles to oxidation. (c) 2011 Elsevier Ltd. All rights reserved.
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收藏
页码：190 / 197
页数：8
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