ALLERGIC INFLAMMATION: ROLE OF CYTOKINES WITH SPECIAL EMPHASIS ON IL-4

被引：27

作者：

Saggini, A. ^{[1
]}

Maccauro, G. ^{[2
]}

Tripodi, D. ^{[3
]}

De Lutiis, M. A. ^{[4
]}

Conti, F. ^{[5
]}

Felaco, P. ^{[4
]}

Fulcheri, M. ^{[6
]}

Galzio, R. ^{[7
]}

Caraffa, A. ^{[8
]}

Antinolfi, P. ^{[8
]}

Felaco, M. ^{[5
]}

Pandolfi, F. ^{[9
]}

Sabatino, G. ^{[10
]}

Neri, G. ^{[11
]}

Shaik-Dasthagirisaheb, Y. B. ^{[12
]}

机构：

[1] Univ Roma Tor Vergata, Dept Dermatol, IT-00133 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Dept Orthopaed, Rome, Italy

[3] Univ G dAnnunzio, Sch Dent, Chieti, Italy

[4] Univ G dAnnunzio, Dept Human Dynam, Chieti, Italy

[5] Vasto Hosp, Gynecol Div, Vasto, Italy

[6] Univ G dAnnunzio, Dept Clin Psychol, Chieti, Italy

[7] Univ Aquila, Dept Hlth Sci, I-67100 Laquila, Italy

[8] Univ Perugia, Orthopaed Div, I-06100 Perugia, Italy

[9] Univ Cattolica Sacro Cuore, Inst Internal Med, Rome, Italy

[10] Univ G dAnnunzio, Div Neonatol, Chieti, Italy

[11] Univ G dAnnunzio, Dept ORL, Chieti, Italy

[12] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2011年 / 24卷 / 02期

关键词：

allergy; inflammation; cytokines; HEPATOCELLULAR-CARCINOMA; INTERFERON-GAMMA; CELLS; MECHANISMS; EXPRESSION; APOPTOSIS; RELEASE; LYMPHOCYTES; ACTIVATION; RESISTANCE;

D O I：

10.1177/039463201102400204

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review examines recent articles on the relationship of cytokines to allergy and inflammation with particular emphasis on interleukin (IL)-4. The objective of this article is therefore to review published studies to identify cytokines consistently involved in allergic inflammation. Proinflammatory cytokines, including IL-4, 1L-5, IL-13 and GM-CSF along with TNF-alpha play a role in allergen-induced airway leukocyte recruitment and these cytokines can be generated by T mast cells and other cells. In addition, IL-9, IL-25, IL-33, IL-17, IL-27 and IFN-gamma are deeply involved in the regulation of asthma. Blocking the effect of these proinflammatory cytokines might provide new therapeutic approaches for the control of allergy and inflammation.

引用

页码：305 / 311

页数：7

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