Precision medicine in type 2 diabetes

被引:56
作者
Prasad, R. B. [1 ]
Groop, L. [1 ,2 ]
机构
[1] Lund Univ, Clin Res Ctr, Dept Clin Sci, Genom Diabet & Endocrinol, Jan Waldenstroms Gata 35, S-20502 Malmo, Sweden
[2] Univ Helsinki, FIMM, Helsinki, Finland
基金
欧洲研究理事会; 芬兰科学院; 瑞典研究理事会;
关键词
diabetes; GENOME-WIDE ASSOCIATION; EARLY METABOLIC MARKERS; LOW-BIRTH-WEIGHT; LONG-TERM RISK; GENETIC-VARIATION; INSULIN; MUTATIONS; ONSET; KIR6.2; VARIANTS;
D O I
10.1111/joim.12859
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The Precision Medicine Initiative defines precision medicine as 'an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment and lifestyle for each person'. This approach will facilitate more accurate treatment and prevention strategies in contrast to a one-size-fits-all approach, in which disease treatment and prevention strategies are developed for generalized usage. Diabetes is clearly more heterogeneous than the conventional subclassification into type 1 and type 2 diabetes. Monogenic forms of diabetes like MODY and neonatal diabetes have paved the way for precision medicine in diabetes, as carriers of unique mutations require unique treatment. Diagnosis of diabetes in the past has been dependent upon measuring one metabolite, glucose. By instead including six variables in a clustering analysis, we could break down diabetes into five distinct subgroups, with better prediction of disease progression and outcome. The severe insulin-resistant diabetes (SIRD) cluster showed the highest risk of kidney disease and highest prevalence of nonalcoholic fatty liver disease, whereas patients in the insulin-deficient cluster 2 (SIDD) had the highest risk of retinopathy. In the future, this will certainly be improved and expanded by including genetic, epigenetic and other biomarker to allow better prediction of outcome and choice of more precise treatment.
引用
收藏
页码:40 / 48
页数:9
相关论文
共 60 条
[1]   A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease [J].
Abul-Husn, N. S. ;
Cheng, X. ;
Li, A. H. ;
Xin, Y. ;
Schurmann, C. ;
Stevis, P. ;
Liu, Y. ;
Kozlitina, J. ;
Stender, S. ;
Wood, G. C. ;
Stepanchick, A. N. ;
Still, M. D. ;
McCarthy, S. ;
O'Dushlaine, C. ;
Packer, J. S. ;
Balasubramanian, S. ;
Gosalia, N. ;
Esopi, D. ;
Kim, S. Y. ;
Mukherjee, S. ;
Lopez, A. E. ;
Fuller, E. D. ;
Penn, J. ;
Chu, X. ;
Luo, J. Z. ;
Mirshahi, U. L. ;
Carey, D. J. ;
Still, C. D. ;
Feldman, M. D. ;
Small, A. ;
Damrauer, S. M. ;
Rader, D. J. ;
Zambrowicz, B. ;
Olson, W. ;
Murphy, A. J. ;
Borecki, I. B. ;
Shuldiner, A. R. ;
Reid, J. G. ;
Overton, J. D. ;
Yancopoulos, G. D. ;
Hobbs, H. H. ;
Cohen, J. C. ;
Gottesman, O. ;
Teslovich, T. M. ;
Baras, A. ;
Mirshahi, T. ;
Gromada, J. ;
Dewey, F. E. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (12) :1096-1106
[2]   Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables [J].
Ahlqvist, Emma ;
Storm, Petter ;
Karajamaki, Annemari ;
Martinell, Mats ;
Dorkhan, Mozhgan ;
Carlsson, Annelie ;
Vikman, Petter ;
Prasad, Rashmi B. ;
Aly, Dina Mansour ;
Almgren, Peter ;
Wessman, Ylva ;
Shaat, Nael ;
Spegel, Peter ;
Mulder, Hindrik ;
Lindholm, Eero ;
Melander, Olle ;
Hansson, Ola ;
Malmqvist, Ulf ;
Lernmark, Ake ;
Lahti, Kaj ;
Forsen, Tom ;
Tuomi, Tiinamaija ;
Rosengren, Anders H. ;
Groop, Leif .
LANCET DIABETES & ENDOCRINOLOGY, 2018, 6 (05) :361-369
[3]   Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women [J].
Arora, Geeti P. ;
Almgren, Peter ;
Brons, Charlotte ;
Thaman, Richa G. ;
Vaag, Allan A. ;
Groop, Leif ;
Prasad, Rashmi B. .
BMC MEDICAL GENOMICS, 2018, 11
[4]   Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes [J].
Bacos, Karl ;
Gillberg, Linn ;
Volkov, Petr ;
Olsson, Anders H. ;
Hansen, Torben ;
Pedersen, Oluf ;
Gjesing, Anette Prior ;
Eiberg, Hans ;
Tuomi, Tiinamaija ;
Almgren, Peter ;
Groop, Leif ;
Eliasson, Lena ;
Vaag, Allan ;
Dayeh, Tasnim ;
Ling, Charlotte .
NATURE COMMUNICATIONS, 2016, 7
[5]   EDITORIAL: The developmental origins of adult disease [J].
D.J.P. Barker .
European Journal of Epidemiology, 2003, 18 (8) :733-736
[6]   QUANTITATIVE-ANALYSIS OF ISLET GLUTAMIC-ACID DECARBOXYLASE-P64 AUTOANTIBODIES IN INSULIN-DEPENDENT DIABETES-MELLITUS [J].
BARMEIER, H ;
AHLMEN, J ;
LANDINOLSSON, M ;
RAJOTTE, RV ;
SUNDKVIST, G ;
WARNOCK, G ;
LERNMARK, A .
AUTOIMMUNITY, 1992, 13 (03) :187-196
[7]   Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study [J].
Becker, Matth S. L. ;
Visser, Loes E. ;
van Schaik, Ron H. N. ;
Hofman, Albert ;
Uitterlinden, Andre G. ;
Stricker, Bruno H. Ch. .
DIABETES, 2009, 58 (03) :745-749
[8]   Quantitative comparison of DNA methylation assays for biomarker development and clinical applications [J].
Bock, Christoph ;
Halbritter, Florian ;
Carmona, Francisco J. ;
Tierling, Sascha ;
Datlinger, Paul ;
Assenov, Yassen ;
Berdasco, Maria ;
Bergmann, Anke K. ;
Booher, Keith ;
Busato, Florence ;
Campan, Mihaela ;
Dahl, Christina ;
Dahmcke, Christina M. ;
Diep, Dinh ;
Fernandez, Agustin F. ;
Gerhauser, Clarissa ;
Haake, Andrea ;
Heilmann, Katharina ;
Holcomb, Thomas ;
Hussmann, Dianna ;
Ito, Mitsuteru ;
Klaever, Ruth ;
Kreutz, Martin ;
Kulis, Marta ;
Lopez, Virginia ;
Nair, Shalima S. ;
Paul, Dirk S. ;
Plongthongkum, Nongluk ;
Qu, Wenjia ;
Queiros, Ana C. ;
Reinicke, Frank ;
Sauter, Guido ;
Schlomm, Thorsten ;
Statham, Aaron ;
Stirzaker, Clare ;
Strogantsev, Ruslan ;
Urdinguio, Rocio G. ;
Walter, Kimberly ;
Weichenhan, Dieter ;
Weisenberger, Daniel J. ;
Beck, Stephan ;
Clark, Susan J. ;
Esteller, Manel ;
Ferguson-Smith, Anne C. ;
Fraga, Mario F. ;
Guldberg, Per ;
Hansen, Lise Lotte ;
Laird, Peter W. ;
Martin-Subero, Jose I. ;
Nygren, Anders O. H. .
NATURE BIOTECHNOLOGY, 2016, 34 (07) :726-+
[9]   Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study [J].
Chambers, John C. ;
Loh, Marie ;
Lehne, Benjamin ;
Drong, Alexander ;
Kriebel, Jennifer ;
Motta, Valeria ;
Wahl, Simone ;
Elliott, Hannah R. ;
Rota, Federica ;
Scott, William R. ;
Zhang, Weihua ;
Tan, Sian-Tsung ;
Campanella, Gianluca ;
Chadeau-Hyam, Marc ;
Yengo, Loic ;
Richmond, Rebecca C. ;
Adamowicz-Brice, Martyna ;
Afzal, Uzma ;
Bozaoglu, Kiymet ;
Mok, Zuan Yu ;
Ng, Hong Kiat ;
Pattou, Francois ;
Prokisch, Holger ;
Rozario, Michelle Ann ;
Tarantini, Letizia ;
Abbott, James ;
Ala-Korpela, Mika ;
Albetti, Benedetta ;
Ammerpohl, Ole ;
Bertazzi, Pier Alberto ;
Blancher, Christine ;
Caiazzo, Robert ;
Danesh, John ;
Gaunt, Tom R. ;
de Lusignan, Simon ;
Gieger, Christian ;
Illig, Thomas ;
Jha, Sujeet ;
Jones, Simon ;
Jowett, Jeremy ;
Kangas, Antti J. ;
Kasturiratne, Anuradhani ;
Kato, Norihiro ;
Kotea, Navaratnam ;
Kowlessur, Sudhir ;
Pitkaeniemi, Janne ;
Punjabi, Prakash ;
Saleheen, Danish ;
Schafmayer, Clemens ;
Soininen, Pasi .
LANCET DIABETES & ENDOCRINOLOGY, 2015, 3 (07) :526-534
[10]  
Chuang JC, 2007, PEDIATR RES, V61, p24R, DOI 10.1203/pdr.0b013e3180457684