Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?

被引：412

作者：

Pui, Ching-Hon ^{[1
,2
,3
]}

Mullighan, Charles G. ^{[2
]}

Evans, William E. ^{[3
,4
]}

Relling, Mary V. ^{[3
,4
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

[3] Univ Tennessee, Ctr Hlth Sci, Memphis, TN 38163 USA

[4] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

来源：

BLOOD | 2012年 / 120卷 / 06期

基金：

美国国家卫生研究院;

关键词：

CHILDRENS-CANCER-GROUP; EVENT-FREE SURVIVAL; HIGH-DOSE METHOTREXATE; DOWN-SYNDROME; T-CELL; VENOOCCLUSIVE DISEASE; ADULT SURVIVORS; B-PROGENITOR; RELAPSE RISK; AIEOP-BFM;

D O I：

10.1182/blood-2012-05-378943

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Improved supportive care, more precise risk stratification, and personalized chemotherapy based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and pharmacogenetics) have pushed the cure rate of childhood acute lymphoblastic leukemia to near 90%. Further increase in cure rate can be expected from the discovery of additional recurrent molecular lesions, coupled with the development of novel targeted treatment through high-throughput genomics and innovative drug-screening systems. We discuss specific areas of research that promise to further refine current treatment and to improve the cure rate and quality of life of the patients. (Blood. 2012;120(6):1165-1174)

引用

页码：1165 / 1174

页数：10

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