Long non-coding RNA XIST exerts oncogenic functions in human nasopharyngeal carcinoma by targeting miR-34a-5p

被引：136

作者：

Song, Peng ^{[1
]}

Ye, Lin-Feng ^{[1
]}

Zhang, Cen ^{[1
]}

Peng, Tao ^{[1
]}

Zhou, Xu-Hong ^{[1
]}

机构：

[1] Wuhan Univ, Zhongnan Hosp, Dept Otorhinolaryngol Head & Neck Surg, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China

来源：

GENE | 2016年 / 592卷 / 01期

关键词：

X inactivate-specific transcript (XIST); Hsa-miRNA-34a-5p (miR-34a-5p); E2F3; Nasopharyngeal carcinoma (NPC); Tumorigenesis; CELL LUNG-CANCER; HEPATOCELLULAR-CARCINOMA; DOWN-REGULATION; PROMOTES PROLIFERATION; TRANSCRIPTION FACTOR; HIGH EXPRESSION; STEM-CELLS; C-MET; E2F3; METASTASIS;

D O I：

10.1016/j.gene.2016.07.055

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Long non-coding RNA (IncRNA) X inactivate-specific transcript (XIST) has been verified as an oncogenic gene in several human malignant tumors, and its dysregulation was closed associated with tumor initiation, development and progression. Nevertheless, whether the aberrant expression of XIST in human nasopharyngeal carcinoma (NPC) is corrected with malignancy, metastasis or prognosis has not been elaborated. Here, we discovered that XIST was up-regulated in NPC tissues and higher expression of XIST contributed to a markedly poorer survival time. In addition, multivariate analysis demonstrated XIST was an independent risk factor for prognosis. XIST over-expression enhanced, while XIST silencing hampered the cell growth in NPC. Additionally, mechanistic analysis revealed that XIST up-regulated the expression of miR-34a-5p targeted gene E2F3 through acting as a competitive 'sponge' of miR-34a-5p. Taking all into account, we concluded that XIST functioned as an oncogene in NPC through up-regulating E2F3 in part through 'spongeing' miR-34a-5p. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：8 / 14

页数：7

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