RNA polymerase I and III: similar yet unique

被引：55

作者：

Khatter, Heena ^{[1
]}

Vorlaender, Matthias K. ^{[1
]}

Mueller, Christoph W. ^{[1
]}

机构：

[1] EMBL, Struct & Computat Biol Unit, Meyerhofstr 1, D-69117 Heidelberg, Germany

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2017年 / 47卷

基金：

欧盟地平线“2020”;

关键词：

STRUCTURAL BASIS; TRANSCRIPTION TERMINATION; MOLECULAR-STRUCTURES; CRYSTAL-STRUCTURE; COMPLEX; SUBUNIT; VISUALIZATION; ARCHITECTURE; RECRUITMENT; MECHANISM;

D O I：

10.1016/j.sbi.2017.05.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The majority of non-protein-coding RNAs present in eukaryotic cells comprises rRNAs, tRNAs and U6 snRNA that are involved in protein biosynthesis and are synthesized by DNA dependent-RNA polymerase I and III. The transcription cycle (initiation, elongation and termination) has similar principles in all three nuclear RNA polymerases with specific features that are reflected back in their structures. Recently, owing to the 'resolution revolution' in electron cryo-microscopy, there has been a significant advancement in the understanding of these molecular machines. Here, we highlight the structure-function adaptation in specificity and activity of these molecular machines and present parallels and distinctions between their transcription mechanisms.

引用

页码：88 / 94

页数：7

共 44 条

[1] Comparative overview of RNA polymerase II and III transcription cycles, with focus on RNA polymerase III termination and reinitiation [J].

Arimbasseri, Aneeshkumar G. ;

Rijal, Keshab ;

Maraia, Richard J. .

TRANSCRIPTION-AUSTIN, 2014, 5 (01) :1-13

[2] Structure of transcribing mammalian RNA polymerase II [J].

Bernecky, Carrie ;

Herzog, Franz ;

Baumeister, Wolfgang ;

Plitzko, Juergen M. ;

Cramer, Patrick .

NATURE, 2016, 529 (7587) :551-+

[3] Structural mechanism for rifampicin inhibition of bacterial RNA polymerase [J].

Campbell, EA ;

Korzheva, N ;

Mustaev, A ;

Murakami, K ;

Nair, S ;

Goldfarb, A ;

Darst, SA .

CELL, 2001, 104 (06) :901-912

[4] The Increase in the Number of Subunits in Eukaryotic RNA Polymerase III Relative to RNA Polymerase II Is due to the Permanent Recruitment of General Transcription Factors [J].

Carter, Robert ;

Drouin, Guy .

MOLECULAR BIOLOGY AND EVOLUTION, 2010, 27 (05) :1035-1043

[5] The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination [J].

Chédin, S ;

Riva, M ;

Schultz, P ;

Sentenac, A ;

Carles, C .

GENES & DEVELOPMENT, 1998, 12 (24) :3857-3871

[6] Architecture of RNA polymerase II and implications for the transcription mechanism [J].

Cramer, P ;

Bushnell, DA ;

Fu, JH ;

Gnatt, AL ;

Maier-Davis, B ;

Thompson, NE ;

Burgess, RR ;

Edwards, AM ;

David, PR ;

Kornberg, RD .

SCIENCE, 2000, 288 (5466) :640-649

[7] Structural basis of transcription:: RNA polymerase II at 2.8 Ångstrom resolution [J].

Cramer, P ;

Bushnell, DA ;

Kornberg, RD .

SCIENCE, 2001, 292 (5523) :1863-1876

[8]

Derenzini M, 1998, AM J PATHOL, V152, P1291

[9] Facilitated recycling pathway for RNA polymerase III [J].

Dieci, G ;

Sentenac, A .

CELL, 1996, 84 (02) :245-252

[10] Structural Basis of RNA Polymerase I Transcription Initiation [J].

Engel, Christoph ;

Gubbey, Tobias ;

Neyer, Simon ;

Sainsbury, Sarah ;

Oberthuer, Christiane ;

Baejen, Carlo ;

Bernecky, Carrie ;

Cramer, Patrick .

CELL, 2017, 169 (01) :120-+

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