Higher levels of prorenin predict development of diabetic retinopathy in patients with type 2 diabetes

被引：14

作者：

Yokota, Harumasa ^{[1
]}

Nagaoka, Taiji ^{[1
]}

Tani, Tomofumi ^{[1
]}

Takahashi, Atsushi ^{[1
]}

Sato, Eiichi ^{[1
]}

Kato, Yuji ^{[1
]}

Yoshida, Akitoshi ^{[1
]}

机构：

[1] Asahikawa Med Coll, Dept Ophthalmol, Asahikawa, Hokkaido 0788510, Japan

来源：

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | 2011年 / 12卷 / 03期

关键词：

Diabetic retinopathy; prorenin; renin-angiotensin system; type; 2; diabetes; RENIN-ANGIOTENSIN SYSTEM; II RECEPTOR ANTAGONIST; MICROVASCULAR COMPLICATIONS; RETINAL NEOVASCULARIZATION; NONPROTEOLYTIC ACTIVATION; SIGNAL-TRANSDUCTION; (PRO)RENIN RECEPTOR; KINETIC ASSAY; CANDESARTAN; PROGRESSION;

D O I：

10.1177/1470320310391327

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The aim was to determine whether serum prorenin levels affect the development of diabetic retinopathy (DR) in type 2 diabetes. Baseline serum prorenin levels were measured in 196 patients (85 males, 111 females) with type 2 diabetes without DR using the antibody-activating direct prorenin assay. The fundi were checked regularly. The participants were divided into two groups based on the serum prorenin levels (high and low). We used Kaplan-Meyer analysis to detect differences in the development of DR between the two groups within the same gender. Kaplan-Meyer analysis showed that males with a high serum prorenin level tended to develop DR earlier and more frequently than males with a low prorenin level (p = 0.004 by the log rank test). However, there was no difference in the development of DR between high and low groups in females (p = 0.58). Serum prorenin levels in males with type 2 diabetes could be a new prognostic indicator of the development of DR.

引用

页码：290 / 294

页数：5