Evaluation of Biochemical Effects of Anelgesic Agents and Conotoxins of Mediterranean Cone (Conus mediterraneus) on Bradykinin and Histamine Causing Pain in Female Sheep (Ovis aries)

被引：3

作者：

Bayazit, Vahdettin ^{[1
]}

机构：

[1] Mus Alparslan Univ, Fac Arts & Sci, Dept Biol, TR-49100 Mus, Turkey

来源：

ASIAN JOURNAL OF ANIMAL AND VETERINARY ADVANCES | 2011年 / 6卷 / 05期

关键词：

Pain; nanoanelgesic; nanoconotoxins; mediterranean cone (Coitus mediterraneus) bradykinin; histamine; GATED SODIUM-CHANNELS; ETHNIC-DIFFERENCES; OMEGA-CONOTOXIN; UNEQUAL BURDEN; VENOM; DISPARITIES; TOLERANCE;

D O I：

10.3923/ajava.2011.499.507

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The purpose of this study was performed to test effects of the nanoanelgesic and nanoconotoxin materials on bradykinin and hystamine causing the various pains. Normal blood histamine values were between 5 mL ( 25 and 65 ng mL(-1)). Blood samples taken as intra venous from six month old female sheep (Ovis aries). In this study, bradykinin and histamine concentrations were selected as 65 ng mL(-1) and levels of chemical analgesic nanoagents are administered as 8 mL (40 ng mL(-1)). Conicamin, Cycloamphilectene 2, Plakohypaphorine D, Pourewic acid A, Cadlinolide C, Petrocortyne A, Petrosaspongiolide M, Petrosaspongiolides M-R, Pseudopterosin N, Seco-pseudopterosin E, Elisabethaclione, Pseudopterosin R, alpha-Conotoxin, mu-conotoxin, omega-conotoxin, Des(Gly1) contryphan R, Contryphan-R, Bromocontyphan-R, Contryphan-Sm, Contryphan-P, Contryphan-R/Tx, Contryphan-Tx, Contryphan-Vn, Leu-contryphan-P, Leu-contryphan-Tx, Glaconryphan-M mu-conotoxins GIIIA, mu-conotoxins GIIIB, mu-conotoxins GIIIC, mu-toxin mu-PIIIA, alpha-conotcodns GI, alpha-conotoxins GIA, alpha-conotoxins GII, alpha-conotoxins MI, astaxanthin, bolinaquinone, cacospongionolide B and Clathriol are decreased significantly bradykinin and hystamin levels in the blood (p<0.01) but delta-conotoxin K-conotoxin are decreased significantly more less than other agents (p<0.05).

引用

页码：499 / 507

页数：9

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