Effectiveness of low-dose and standard-dose tamsulosin in the treatment of distal ureteric stones: a randomized controlled study

被引：42

作者：

Lojanapiwat, B. ^{[1
]}

Kochakarn, W. ^{[2
]}

Suparatchatpan, N. ^{[3
]}

Lertwuttichaikul, K. ^{[3
]}

机构：

[1] Chiang Mai Univ, Div Urol, Dept Surg, Chiang Mai 50200, Thailand

[2] Ramathibodi Hosp, Div Urol, Dept Surg, Bangkok, Thailand

[3] Maharat Nakornratchasima Hosp, Div Urol, Nakornratchasima, Thailand

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2008年 / 36卷 / 03期

关键词：

distal ureteric stones; ureteric colic pain; ureterolith explusion; tamsulosin; diclofenac; alpha-adrenergic antagonist; Asia; Thailand;

D O I：

10.1177/147323000803600318

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Low-dose (0.2 mg/day) and standard-dose (0.4 mg/day) tamsulosin were studied in a randomized controlled trial of 75 outpatients with distal ureteroliths in Thailand. Group 1 (n = 25; control) received oral sodium diclofenac 50 mg twice a day for 10 days; group 2 (n = 25) received oral sodium diclofenac 50 mg twice a day for 10 days, with oral tamsulosin 0.2 mg once a day up to 28 days; and group 3 (n = 25) received oral sodium diclofenac 50 mg twice a day for 10 days, with oral tamsulosin 0.4 mg once a day up to 28 days. For groups 1, 2 and 3, respectively, the expulsion rates were 4%, 40% and 68% (significantly different for group 1 vs group 2, and for group 1 vs group 3) and mean expulsion times were 23.00, 9.30 and 10.76 days. Both doses of tamsulosin increased stone expulsion rate and decreased expulsion time in comparison with the control, and have been shown to be safe and effective in Asian patients.

引用

页码：529 / 536

页数：8

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