Chromatin unfolding and activation by HMGN chromosomal proteins

被引：143

作者：

Bustin, M ^{[1
]}

机构：

[1] NCI, Prot Sect, Met Lab, Div Basic Sci,NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(01)01855-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The high mobility group N (HMGN) proteins are a family of nuclear proteins that binds to nucleosomes. changes the architecture of chromatin, and enhances transcription and replication from chromatin templates. The intracellular organization of the HMGN (previously known as HMG-14/17) proteins is dynamic and is related to both cell-cycle and transcriptional events. These proteins roam the nucleus, perhaps as part of multiprotein complexes, and their target interactions are modulated by posttranslational modifications. Functional studies on HMGN proteins provide insights into the molecular mechanisms by which structural proteins affect DNA-dependent activities in the context of chromatin.

引用

页码：431 / 437

页数：7

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