Photophysical Probes To Assess the Potential of Cholic Acid Aggregates as Drug Carriers

被引：28
作者：
Gomez-Mendoza, Miguel [1 ]
Nuin, Edurne [1 ]
Andreu, Inmaculada [1 ]
Luisa Mann, M. [1 ]
Miranda, Miguel A. [1 ]
机构：
[1] Univ Politecn Valencia, Inst Univ Mixto Tecnol Quim UPV CSIC, Valencia 46022, Spain
来源：
JOURNAL OF PHYSICAL CHEMISTRY B | 2012年 / 116卷 / 34期
关键词：
BILE-SALT MICELLES; BETA-CYCLODEXTRIN; NAPROXEN; SYSTEMS; DERIVATIVES; DYNAMICS;
D O I：
10.1021/jp304708y
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The two enantiomers of the nonsteroidal antiinflammatory drug naproxen and of its methyl ester have been selected as representative probes with markedly different hydrophobicity to assess the potential of cholic acid aggregates as drug carriers by means of photophysical techniques. The different distribution of the probes between bulk solution and aggregates has been assessed by quenching of their singlet and triplet excited states by iodide and nitrite anions, respectively. This straightforward photophysical methodology can, in principle, be extended to a variety of drugs containing a photoactive chromophore.
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收藏
页码：10213 / 10218
页数：6
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