In Vitro and In Vivo Uncaging and Bioluminescence Imaging by Using Photocaged Upconversion Nanoparticles

被引：410

作者：

Yang, Yanmei ^{[2
]}

Shao, Qing ^{[2
]}

Deng, Renren ^{[1
]}

Wang, Chao ^{[4
]}

Teng, Xue ^{[6
]}

Cheng, Kai ^{[5
]}

Cheng, Zhen ^{[5
]}

Huang, Ling ^{[6
]}

Liu, Zhuang ^{[4
]}

Liu, Xiaogang ^{[1
,3
]}

Xing, Bengang ^{[2
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore

[3] ASTAR, Inst Mat Res & Engn, Singapore 117602, Singapore

[4] Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat, Suzhou, Peoples R China

[5] Stanford Univ, Mol Imaging Program Stanford MIPS, Dept Radiol, Med Ctr, Stanford, CA 94305 USA

[6] Nanyang Technol Univ, Div Biomed Engn, Sch Chem & Biomed Engn, Singapore 637371, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 13期

关键词：

bioluminescence; D-luciferin; nanoparticles; photochemistry; upconversion; NEAR-INFRARED LIGHT; UPCONVERTING NANOPARTICLES; SPATIOTEMPORAL CONTROL; PHOTODYNAMIC THERAPY; IRON-OXIDE; LUMINESCENCE; NANOCRYSTALS; FLUORESCENCE; CORE; EXPRESSION;

D O I：

10.1002/anie.201107919

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Trading up: A bioimaging system that is based on caged D-luciferin/ upconversion nanoparticle conjugate has been developed. The nanoparticles upconvert near-infrared light into UV light, which triggers the photorelease of D-luciferin (see scheme) and leads to enhanced fluorescence and bioluminescence signals in vitro and in vivo. The use of near-infrared light enables deep penetration into tissue in vivo with minimum cellular damage. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3125 / 3129

页数：5

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