Serum N-Terminal Pro-B-Type Natriuretic Peptide Levels Are Associated With Functional Capacity in Patients With Peripheral Arterial Disease

被引：11

作者：

Fan, Jin ^{[1
]}

Jouni, Hayan ^{[2
]}

Khaleghi, Mahyar ^{[3
]}

Bailey, Kent R. ^{[4
]}

Kullo, Iftikhar J. ^{[1
]}

机构：

[1] Mayo Clin, Div Cardiovasc Dis, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Med, Rochester, MN 55905 USA

[3] Georgetown Univ Hosp, Washington Hosp Ctr, Dept Med, Washington, DC 20007 USA

[4] Mayo Clin, Dept Biomed Informat & Stat, Rochester, MN 55905 USA

来源：

ANGIOLOGY | 2012年 / 63卷 / 06期

基金：

美国国家卫生研究院;

关键词：

N-terminal pro-B-type natriuretic peptide; natriuretic peptides; functional capacity; peripheral arterial disease; ANKLE-BRACHIAL INDEX; INTERMITTENT CLAUDICATION; WALKING DISTANCE; WAVE REFLECTION; STIFFNESS; MANAGEMENT; ANGIOGENESIS; DIAGNOSIS; PROTEIN; TIME;

D O I：

10.1177/0003319711423095

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

We hypothesized that higher serum levels of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) are associated with lower functional capacity in patients with peripheral arterial disease ([PAD] n = 481, mean age 67, 68% men). Functional capacity was quantified as distance walked on a treadmill for 5 minutes. Patients were divided into 3 groups according to the distance walked: >144 yards (group 1, n = 254); 60 to 144 yards (group 2, n = 80); <60 yards or did not walk (group 3, n = 147). The association between NT-pro-BNP levels and the ordinal 3-level walking distance was assessed using multivariable ordinal logistic regression analyses that adjusted for several possible confounding variables. Higher levels of NT-pro-BNP were associated with a lower ordinal walking category independent of possible confounders (odds ratio [OR] 1.51, 95% confidence interval [CI] 1.28-1.77; P < .001). In conclusion, higher levels of NT-pro-BNP are independently associated with lower functional capacity in patients with PAD and may be a marker of hemodynamic stress in these patients.

引用

页码：435 / 442

页数：8

共 43 条

[1] RETRACTED: Ramipril reduces large-artery stiffness in peripheral arterial disease and promotes elastogenic remodeling in cell culture (Retracted Article) [J].