Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration

被引：383

作者：

Chauhan, Vikash P. ^{[2
,3
,4
]}

Popovic, Zoran ^{[1
]}

Chen, Ou ^{[1
]}

Cui, Jian ^{[1
]}

Fukumura, Dai ^{[2
,3
]}

Bawendi, Moungi G. ^{[1
]}

Jain, Rakesh K. ^{[2
,3
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA

[4] Harvard Univ, Harvard Sch Engn & Appl Sci, Cambridge, MA 02138 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 48期

关键词：

cancer; imaging agents; luminescence; microscopy; nanoparticles; EXTRACELLULAR-MATRIX; SEEDED GROWTH; DIFFUSION; LIPOSOMES; TRANSPORT; PARTICLES; XENOGRAFT; DELIVERY; IMPROVES; MICROENVIRONMENT;

D O I：

10.1002/anie.201104449

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Shape dependent: Fluorescent quantum-dot-based nanospheres and nanorods with identical hydrodynamic size and surface properties but different aspect ratios were developed for real-time in vivo tumor imaging. The nanorods exhibited superior transport and distribution into mammary tumors in vivo versus nanospheres of similar plasma half-life. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：11417 / 11420

页数：4

相关论文

共 35 条

[1] In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy [J].

Brown, EB ;

Campbell, RB ;

Tsuzuki, Y ;

Xu, L ;

Carmeliet, P ;

Fukumura, D ;

Jain, RK .

NATURE MEDICINE, 2001, 7 (07) :864-868

[2] Preparation of ultrafine silica- and PEG-coated magnetite particles [J].

Butterworth, MD ;

Illum, L ;

Davis, SS .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2001, 179 (01) :93-102

[3]

Campbell RB, 2002, CANCER RES, V62, P6831

[4] Synthesis and micrometer-scale assembly of colloidal CdSe/CdS nanorods prepared by a seeded growth approach [J].

Carbone, Luigi ;

Nobile, Concetta ;

De Giorgi, Milena ;

Sala, Fabio Delia ;

Morello, Giovanni ;

Pompa, Pierpaolo ;

Hytch, Martin ;

Snoeck, Etienne ;

Fiore, Angela ;

Franchini, Isabella R. ;

Nadasan, Monica ;

Silvestre, Albert F. ;

Chiodo, Letizia ;

Kudera, Stefan ;

Cingolani, Roberto ;

Krahne, Roman ;

Manna, Liberato .

NANO LETTERS, 2007, 7 (10) :2942-2950

[5] Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies [J].

Chauhan, Vikash P. ;

Stylianopoulos, Triantafyllos ;

Boucher, Yves ;

Jain, Rakesh K. .

ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, VOL 2, 2011, 2 :281-298

[6] Multiscale Measurements Distinguish Cellular and Interstitial Hindrances to Diffusion In Vivo [J].

Chauhan, Vikash P. ;

Lanning, Ryan M. ;

Diop-Frimpong, Benjamin ;

Mok, Wilson ;

Brown, Edward B. ;

Padera, Timothy P. ;

Boucher, Yves ;

Jain, Rakesh K. .

BIOPHYSICAL JOURNAL, 2009, 97 (01) :330-336

[7] Two-point microrheology of inhomogeneous soft materials [J].

Crocker, JC ;

Valentine, MT ;

Weeks, ER ;

Gisler, T ;

Kaplan, PD ;

Yodh, AG ;

Weitz, DA .

PHYSICAL REVIEW LETTERS, 2000, 85 (04) :888-891

[8] HINDERED TRANSPORT OF LARGE MOLECULES IN LIQUID-FILLED PORES [J].

DEEN, WM .

AICHE JOURNAL, 1987, 33 (09) :1409-1425

[9] EFFECTS OF MOLECULAR-SIZE AND CONFIGURATION ON DIFFUSION IN MICROPOROUS MEMBRANES [J].

DEEN, WM ;

BOHRER, MP ;

EPSTEIN, NB .

AICHE JOURNAL, 1981, 27 (06) :952-959

[10]

Dellian M, 2000, BRIT J CANCER, V82, P1513

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