A NOVEL MONOCLONAL ANTIBODY AGAINST HUMAN CD80 AND ITS IMMUNE PROTECTION IN A MOUSE LUPUS-LIKE DISEASE

被引：27

作者：

Shi, Q. ^{[2
]}

Gao, Z. Y. ^{[1
]}

Xie, F. ^{[3
]}

Wang, L. F. ^{[4
]}

Gu, Y. P. ^{[3
]}

Yang, T. J. ^{[1
]}

Huang, L. ^{[1
]}

Qian, Q. H. ^{[5
]}

Qiu, Y. H. ^{[1
]}

机构：

[1] Soochow Univ, Coll Med, Dept Immunol, Suzhou 215123, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Dept Orthoped, Suzhou 215123, Peoples R China

[3] Soochow Univ, Coll Med, Dept Pathol, Suzhou 215123, Peoples R China

[4] Soochow Univ, Children Hosp, Dept Nephrol, Suzhou 215123, Peoples R China

[5] Soochow Univ, Affiliated Hosp 1, Dept Dermatol, Suzhou 215123, Peoples R China

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2011年 / 24卷 / 03期

关键词：

anti-human CD80 antibody; systemic lupus erythematosus; co-stimulatory molecule; T-CELLS; B-CELLS; BALB/C MICE; EXPRESSION; COSTIMULATION; MOLECULES; B7-1; AUTOIMMUNITY; ACTIVATION; BLOCKADE;

D O I：

10.1177/039463201102400304

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Blockade of the interactions between CD28/CTLA-4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), is an attractive means to induce antigen-specific peripheral tolerance in autoimmune disease and organ transplantation. In this study, we generated and characterized a monoclonal antibody (Clone 4E5) against human CD80. 4E5 could recognize both human and mouse CD80 and suppress mixed lymphocyte reaction in vitro. To investigate their potency for clinical use, we further administrated 4E5 to a mouse lupus-like disease model (C57BL/J6) induced by Pristane. 4E5 could inhibit the immune response and attenuate the severity of lupus-like disease. The data showed 4E5 function and suggested that blockade of CD80/CD28 co-stimulatory signal pathway with 4E5 is a promising strategy to decelerate the progression of lupus-like disease and other autoimmune diseases.

引用

页码：583 / 593

页数：11

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