Protein export at the ER: loading big collagens into COPII carriers

被引：71

作者：

Malhotra, Vivek ^{[1
,2
]}

Erlmann, Patrik ^{[1
]}

机构：

[1] Ctr Genom Regulat CRG, Dept Cell & Dev Biol, Barcelona 08003, Spain

[2] ICREA, Barcelona, Spain

来源：

EMBO JOURNAL | 2011年 / 30卷 / 17期

关键词：

collagen; COPII; cTAGE5; endoplasmic reticulum; TANGO1; VESICLE FORMATION; SMALL GTPASE; EXIT SITES; EXPRESSION; TRANSPORT; MECHANISMS; SAR1P; MUTATIONS; SECRETION; BINDING;

D O I：

10.1038/emboj.2011.255

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

COPII vesicles mediate the export of secretory cargo from endoplasmic reticulum (ER) exit sites. However, of 60-90 nm diameter COPII vesicles are too small to accommodate secreted molecules such as the collagens. The ER exit site-located proteins TANGO1 and cTAGE5 are required for the transport of collagens and therefore provide a means to understand the export of big cargo and the mechanism of COPII carrier size regulation commensurate with cargo dimensions. The EMBO Journal (2011) 30, 3475-3480. doi:10.1038/emboj.2011.255

引用

页码：3475 / 3480

页数：6

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