Successful Treatment of Postneurosurgical Ventriculitis Caused by Extensively Drug-resistant Acinetobacter baumannii in a Child: Case Report

被引：1

作者：

Yang, Rui ^{[1
]}

Li, Fang ^{[2
]}

Mao, Weiwei ^{[3
]}

Wei, Xin ^{[1
]}

Liu, Xinzhu ^{[1
]}

Guo, Xiaowen ^{[1
]}

Luo, Wentao ^{[1
]}

Liu, Yan ^{[1
]}

Zhang, Jian ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Clin Pharm, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Pharm Management Dept, Xinhua Hosp, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Pediat Neurosurg, Shanghai, Peoples R China

来源：

JUNDISHAPUR JOURNAL OF MICROBIOLOGY | 2021年 / 14卷 / 12期

关键词：

Acinetobacter baumannii; Ventriculitis; Pediatrics; Tigecycline; Polymyxin B; MULTIDRUG-RESISTANT; CEFOPERAZONE-SULBACTAM; TIGECYCLINE; MENINGITIS; COLISTIN;

D O I：

10.5812/jjm.118114

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Introduction: The incidence of postneurosurgical Acinetobacter baumannii ventriculitis/meningitis, primarily due to drugresistant strains, has increased considerably in recent years. However, limited therapeutic options are available because most antibiotics poorly penetrate the blood-brain barrier, especially in pediatric patients. Case Presentation: A five-year-old boy developed ventriculitis due to extensively drug-resistant A. baumannii (XDRAB) after bilateral frontal external ventricular drainage for spontaneous intraventricular hemorrhage. Theboywassafelyandsuccessfully treated with intraventricular (IVT)/intrathecal (ITH) polymyxin B together with intravenous tigecycline plus cefoperazone/sulbactam. Conclusions: In the present case, postneurosurgical XDRAB ventriculitis was closely associated with intraventricular hemorrhage and the placement of external ventricular drainage. IVT/ITH polymyxin B combined with intravenous tigecycline and cefoperazone sulbactam could be a therapeutic option against XDRAB ventriculitis in children.

引用

页数：6

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