Species-Specific Interactions of Src Family Tyrosine Kinases Regulate Chlamydia Intracellular Growth and Trafficking

被引:4
作者
Elwell, Cherilyn A. [1 ,2 ]
Kierbel, Arlinet [3 ]
Engel, Joanne N. [1 ,2 ,4 ]
机构
[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Microbial Pathogenesis & Host Def Program, San Francisco, CA 94143 USA
[4] Inst Pasteur, Montevideo, Uruguay
关键词
HELICOBACTER-PYLORI CAGA; ESCHERICHIA-COLI RECEPTOR; MICROTUBULE NETWORK; TRACHOMATIS TARP; C-FYN; PHOSPHORYLATION; PROTEIN; CELLS; ABNORMALITIES; INFECTION;
D O I
10.1128/mBio.00082-11
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Src family kinases (SFKs) regulate key cellular processes and are emerging as important targets for intracellular pathogens. In this commentary, we briefly review the role of SFKs in bacterial pathogenesis and highlight new work on the role of SFKs during the intracellular cycle of Chlamydia species.
引用
收藏
页数:2
相关论文
共 24 条
[21]   Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo [J].
Selbach, M ;
Moese, S ;
Hauck, CR ;
Meyer, TF ;
Backert, S .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (09) :6775-6778
[22]   Src, cortactin and Arp2/3 complex are required for E-cadherin-mediated internalization of Listeria into cells [J].
Sousa, Sandra ;
Cabanes, Didier ;
Bougneres, Laurence ;
Lecuit, Marc ;
Sansonetti, Philippe ;
Tran-Van-Nhieu, Guy ;
Cossart, Pascale .
CELLULAR MICROBIOLOGY, 2007, 9 (11) :2629-2643
[23]   c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs [J].
Stein, M ;
Bagnoli, F ;
Halenbeck, R ;
Rappuoli, R ;
Fantl, WJ ;
Covacci, A .
MOLECULAR MICROBIOLOGY, 2002, 43 (04) :971-980
[24]   Tyrosine kinase signaling and type III effectors orchestrating Shigella invasion [J].
Van Nhieu, GT ;
Enninga, J ;
Sansonetti, P ;
Grompone, G .
CURRENT OPINION IN MICROBIOLOGY, 2005, 8 (01) :16-20