Species-Specific Interactions of Src Family Tyrosine Kinases Regulate Chlamydia Intracellular Growth and Trafficking

被引：4

作者：

Elwell, Cherilyn A. ^{[1
,2
]}

Kierbel, Arlinet ^{[3
]}

Engel, Joanne N. ^{[1
,2
,4
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Microbial Pathogenesis & Host Def Program, San Francisco, CA 94143 USA

[4] Inst Pasteur, Montevideo, Uruguay

来源：

MBIO | 2011年 / 2卷 / 03期

关键词：

HELICOBACTER-PYLORI CAGA; ESCHERICHIA-COLI RECEPTOR; MICROTUBULE NETWORK; TRACHOMATIS TARP; C-FYN; PHOSPHORYLATION; PROTEIN; CELLS; ABNORMALITIES; INFECTION;

D O I：

10.1128/mBio.00082-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Src family kinases (SFKs) regulate key cellular processes and are emerging as important targets for intracellular pathogens. In this commentary, we briefly review the role of SFKs in bacterial pathogenesis and highlight new work on the role of SFKs during the intracellular cycle of Chlamydia species.

引用

页数：2

共 24 条

[1] Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells [J].

Bougnères, L ;

Girardin, SE ;

Weed, SA ;

Karginov, AV ;

Olivo-Marin, JC ;

Parsons, JT ;

Sansonetti, PJ ;

Van Nhieu, GT .

JOURNAL OF CELL BIOLOGY, 2004, 166 (02) :225-235

[2] Regulation, substrates and functions of src [J].

Brown, MT ;

Cooper, JA .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1996, 1287 (2-3) :121-149

[3] Chlamydia trachomatis utilizes the host cell microtubule network during early events of infection [J].

Clausen, JD ;

Christiansen, G ;

Holst, HU ;

Birkelund, S .

MOLECULAR MICROBIOLOGY, 1997, 25 (03) :441-449

[4] Androgen and Src signaling regulate centrosome activity [J].

Colello, Diane ;

Reverte, Carlos G. ;

Ward, Rachel ;

Jones, Christopher W. ;

Magidson, Valentin ;

Khodjakov, Alexey ;

LaFlamme, Susan E. .

JOURNAL OF CELL SCIENCE, 2010, 123 (12) :2093-2101

[5] RNA interference screen identifies AbI kinase and PDGFR signaling in Chlamydia trachomatis entry [J].

Elwell, Cherilyn A. ;

Ceesay, Alhaji ;

Kim, Jung Hwa ;

Kalman, Daniel ;

Engel, Joanne N. .

PLOS PATHOGENS, 2008, 4 (03)

[6] Chlamydia trachomatis causes centrosomal defects resulting in chromosomal segregation abnormalities [J].

Grieshaber, Scott S. ;

Grieshaber, Nicole A. ;

Miller, Natalie ;

Hackstadt, Ted .

TRAFFIC, 2006, 7 (08) :940-949

[7] Chlamydia trachomatis uses host cell dynein to traffic to the microtubule-organizing center in a p50 dynamitin-independent process [J].

Grieshaber, SS ;

Grieshaber, NA ;

Hackstadt, T .

JOURNAL OF CELL SCIENCE, 2003, 116 (18) :3793-3802

[8] Clustering transfers the translocated Escherichia coli receptor into lipid rafts to stimulate reversible activation of c-Fyn [J].

Hayward, Richard D. ;

Hume, Peter J. ;

Humphreys, Daniel ;

Phillips, Neil ;

Smith, Katherine ;

Koronakis, Vassilis .

CELLULAR MICROBIOLOGY, 2009, 11 (03) :433-441

[9] SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein [J].

Higashi, H ;

Tsutsumi, R ;

Muto, S ;

Sugiyama, T ;

Azuma, T ;

Asaka, M ;

Hatakeyama, M .

SCIENCE, 2002, 295 (5555) :683-686

[10] Chlamydia trachomatis tarp is phosphorylated by src family tyrosine kinases [J].

Jewett, Travis J. ;

Dooley, Cheryl A. ;

Mead, David J. ;

Hackstadt, Ted .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 371 (02) :339-344

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