Metabolites Produced by the Oral Commensal Bacterium Corynebacterium durum Extend the Lifespan of Caenorhabditis elegans via SIR-2.1 Overexpression

被引：22

作者：

Kim, Jun Hyeong ^{[1
]}

Bang, In Hyuk ^{[2
]}

Noh, Yun Jeong ^{[3
]}

Kim, Dae Keun ^{[1
]}

Bae, Eun Ju ^{[4
]}

Hwang, In Hyun ^{[1
]}

机构：

[1] Woosuk Univ, Dept Pharm, Wonju 55338, Jeonbuk, South Korea

[2] Chonbuk Natl Univ, Dept Biochem, Sch Med, Jeonju 54896, Jeonbuk, South Korea

[3] RDA, Natl Inst Anim Sci, Wonju 55365, Jeonbuk, South Korea

[4] Chonbuk Natl Univ, Coll Pharm, Jeonju 54896, Jeonbuk, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

human microbiota; lifespan-extending activities; Corynebacterium durum; Caenorhabditis elegans; phenethylamine; N-acetylphenethylamine; SIR-2; 1; HUMAN MICROBIOME; SIRTUINS; HEALTH; FAMILY;

D O I：

10.3390/ijms21062212

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human microbiota is heavily involved in host health, including the aging process. Based on the hypothesis that the human microbiota manipulates host aging via the production of chemical messengers, lifespan-extending activities of the metabolites produced by the oral commensal bacterium Corynebacterium durum and derivatives thereof were evaluated using the model organism Caenorhabditis elegans. Chemical investigation of the acetone extract of a C. durum culture led to the identification of monoamines and N-acetyl monoamines as major metabolites. Phenethylamine and N-acetylphenethylamine induced a potent and dose-dependent increase of the C. elegans lifespan, up to 21.6% and 19.9%, respectively. A mechanistic study revealed that the induction of SIR-2.1, a highly conserved protein associated with the regulation of lifespan, was responsible for the observed increased longevity.

引用

页数：12