The antioxidant effect of β-Glucan on oxidative stress status in experimental spinal cord injury in rats

被引：57
作者：
Kayali, H [1 ]
Ozdag, MF
Kahraman, S
Aydin, A
Gonul, E
Sayal, A
Odabasi, Z
Timurkaynak, E
机构：
[1] Gulhane Mil Med Acad, Dept Neurosurg, TR-06018 Ankara, Turkey
[2] Gulhane Mil Med Acad, Dept Neurol, Ankara, Turkey
[3] Gulhane Mil Med Acad, Dept Pharmaceut Toxicol, Ankara, Turkey
来源：
NEUROSURGICAL REVIEW | 2005年 / 28卷 / 04期
关键词：
beta-Glucan; spinal cord injury; lipid peroxidation;
D O I：
10.1007/s10143-005-0389-2
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This study was performed to investigate the antioxidant effect of beta-Glucan in experimental spinal cord injury (SCI). Injury was produced using weight-drop technique in rats. beta-Glucan was given by intraperitoneal injection following trauma. The rats were sacrificed at the sixth day of injury. Oxidative stress status was assessed by measuring the spinal cord tissue content of Malonyldialdehyde (MDA), Superoxide Dismutase (SOD) and Gluthatione Peroxidase (GSH-Px) activities. No effect of beta-Glucan on SOD and MDA activities was found but, GSH-Px levels were found to decrease to the baseline (preinjury) levels when it was compared to untreated group (U=0.000; p=0.002). According to our results, beta-Glucan works like a scavenger and has an antioxidant effect on lipid peroxidation in spinal cord injury.
引用
收藏
页码：298 / 302
页数：5
相关论文
共 66 条
[21]   LACTATE AND PYRUVATE METABOLISM IN INJURED CAT SPINAL-CORD BEFORE AND AFTER A SINGLE LARGE INTRAVENOUS DOSE OF METHYLPREDNISOLONE [J].
BRAUGHLER, JM ;
HALL, ED .
JOURNAL OF NEUROSURGERY, 1983, 59 (02) :256-261
[22]   CORRELATION OF METHYLPREDNISOLONE LEVELS IN CAT SPINAL-CORD WITH ITS EFFECTS ON (NA+ + K+)-ATPASE, LIPID-PEROXIDATION, AND ALPHA-MOTOR NEURON FUNCTION [J].
BRAUGHLER, JM ;
HALL, ED .
JOURNAL OF NEUROSURGERY, 1982, 56 (06) :838-844
[23]  
BROWDER W, 1987, SURGERY, V102, P206
[24]  
BROWDER W, 1990, ANN SURG, V211, P605
[25]  
Czop J K, 1989, Prog Clin Biol Res, V297, P287
[26]  
DEMEDIUK P, 1985, PROG BRAIN RES, V63, P1
[27]   PATHOLOGICAL FINDINGS IN ACUTE EXPERIMENTAL SPINAL CORD TRAUMA [J].
DUCKER, TB ;
KINDT, GW ;
KEMPE, LG .
JOURNAL OF NEUROSURGERY, 1971, 35 (06) :700-+
[28]   PHARMACOTHERAPY IN SPINAL-CORD INJURY - A CRITICAL-REVIEW OF RECENT DEVELOPMENTS [J].
FADEN, AI .
CLINICAL NEUROPHARMACOLOGY, 1987, 10 (03) :193-204
[29]   GRADED POSTISCHEMIC REOXYGENATION REDUCES LIPID-PEROXIDATION AND REPERFUSION INJURY IN THE RABBIT SPINAL-CORD [J].
FERCAKOVA, A ;
HALAT, G ;
MARSALA, M ;
LUKACOVA, N ;
MARSALA, J .
BRAIN RESEARCH, 1992, 593 (02) :159-167
[30]  
FERRARI R, 1991, AM J MED S3C, V91, P955
1234567