Paliperidone-Associated Sialorrhea A Case Report With Review of Current Literature

被引:3
作者
Burk, Bradley G. [1 ]
Donaldson, Victoria [2 ]
Jackson, Cherry W. [2 ,4 ,5 ]
Cates, Marshall E. [3 ]
Birur, Badari [4 ,5 ]
机构
[1] Univ Alabama Birmingham, Dept Pharm, Med Ctr, JT 1728,619 19th St S, Birmingham, AL 35249 USA
[2] Auburn Univ, Harrison Coll Pharm, Auburn, AL 36849 USA
[3] Samford Univ, McWhorter Sch Pharm, Homewood, AL USA
[4] Univ Alabama Birmingham, Med Ctr, Dept Psychiat & Behav Neurobiol, Birmingham, AL 35249 USA
[5] Heersink Sch Med, Birmingham, AL USA
关键词
paliperidone; second-generation antipsychotic; sialorrhea; hypersalivation; supratherapeutic; CLOZAPINE; TOLERABILITY;
D O I
10.1097/JCP.0000000000001588
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Purpose/Background Antipsychotic-associated sialorrhea is a problematic adverse effect with potentially negative consequences on quality of life and medication adherence. While clozapine is the antipsychotic that is most associated with sialorrhea, there have been published reports of other second-generation antipsychotics associated with sialorrhea, including aripiprazole, olanzapine, quetiapine, and risperidone. Although drooling is mentioned within the package insert for paliperidone, to date there have been minimal published reports in which paliperidone is implicated as the offending agent. Methods/Procedures Here, we present a case of sialorrhea in a 56-year-old man with schizoaffective disorder who had a supratherapeutic paliperidone level after both oral and intramuscular paliperidone use. Findings/Results Paliperidone was ultimately cross tapered to aripiprazole, and the patient was given atropine drops and benztropine with resolution of the sialorrhea. We provide a review of the literature regarding the other available reports of paliperidone-associated sialorrhea, possible mechanisms behind pathophysiology, as well as reports from the World Health Organization and Food and Drug Administration adverse event reporting systems. Implications/Conclusions Clinicians should be aware of the potential for paliperidone and other nonclozapine second-generation antipsychotics to be associated with sialorrhea, especially given the increased frequency of their use for a variety of psychiatric disorders.
引用
收藏
页码:480 / 484
页数:5
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