Proficient synthesis of bioactive annulated pyrimidine derivatives: A review

被引：42

作者：

Bhat, Ajmal R. ^{[1
]}

Dongre, Rajendra S. ^{[1
]}

Naikoo, Gowhar A. ^{[2
]}

Hassan, Israr U. ^{[2
]}

Ara, Tabassum ^{[3
]}

机构：

[1] RTM Nagpur Univ, Dept Chem, Nagpur 44003, Maharashtra, India

[2] Dhofar Univ, Coll Arts & Appl Sci, Dept Math & Sci, Salalah 2112509, Oman

[3] NIT Hazratbal, Dept Chem, Srinagar 190006, Kashmir, India

来源：

JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE | 2017年 / 11卷 / 06期

关键词：

Pyrano[2,3-d]pyrimidines; Pyrido[2,3-d]pyrimidines; Pyrido[2,3-d; 5-6-d]dipyrimidines; Barbituric acid/Thio-barbituric acid; Aromatic aldehydes; 6-aminouracil; GREEN CHEMISTRY; MICROWAVE; CATALYST;

D O I：

10.1016/j.jtusci.2017.05.005

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Syntheses of bioactive annulated pyrimidine derivatives are the most significant tasks in N-heterocyclic chemistry because these compounds have proved to be very attractive and useful for the design of new molecular frameworks of potential drugs with varying pharmacological activities. This review paper summarizes the one-pot multicomponent synthesis of annulated nitrogen- and oxygen containing heterocycles, such as pyrano[2,3-d]pyrimidines, pyrido[2,3-d]pyrimidines and pyrido[2,3-d;5-6-d]dipyrimidines. The synthetic procedure is based on the chemistry of the domino Knoevenagel-Michael addition mechanism. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of Taibah University. This is an open access article under the CC BY-NC-ND license

引用

页码：1047 / 1069

页数：23

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