Regulatory networks in embryo-derived pluripotent stem cells

被引：519

作者：

Boiani, M ^{[1
]}

Schöler, HR ^{[1
]}

机构：

[1] Max Planck Inst Mol Biomed, Dept Cell & Dev Biol, D-48149 Munster, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 11期

关键词：

D O I：

10.1038/nrm1744

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian development requires the specification of over 200 cell types from a single totipotent cell. Investigation of the regulatory networks that are responsible for pluripotency in embryo-derived stem cells is fundamental to understanding mammalian development and realizing therapeutic potential. Extracellular signals and second messengers modulate cell-autonomous regulators such as OCT4, SOX2 and Nanog in a combinatorial complexity. Knowledge of this circuitry might reveal how to achieve phenotypic changes without the genetic manipulation of Oct4, Nanog and other toti/pluripotency-associated genes.

引用

页码：872 / 884

页数：13

共 135 条

[21] Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells [J].

Burdon, T ;

Stracey, C ;

Chambers, I ;

Nichols, J ;

Smith, A .

DEVELOPMENTAL BIOLOGY, 1999, 210 (01) :30-43

[22] Wnt signaling: a common theme in animal development [J].

Cadigan, KM ;

Nusse, R .

GENES & DEVELOPMENT, 1997, 11 (24) :3286-3305

[23] Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells [J].

Chambers, I ;

Colby, D ;

Robertson, M ;

Nichols, J ;

Lee, S ;

Tweedie, S ;

Smith, A .

CELL, 2003, 113 (05) :643-655

[24] Embryonic stem cell differentiation: The role of extracellular factors [J].

Czyz, J ;

Wobus, AM .

DIFFERENTIATION, 2001, 68 (4-5) :167-174

[25] INTERACTION BETWEEN A NOVEL F9-SPECIFIC FACTOR AND OCTAMER-BINDING PROTEINS IS REQUIRED FOR CELL-TYPE-RESTRICTED ACTIVITY OF THE FIBROBLAST GROWTH-FACTOR-4 ENHANCER [J].

DAILEY, L ;

YUAN, HB ;

BASILICO, C .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (12) :7758-7769

[26] Reflections on STAT3, STAT5, and STAT6 as fat STATs [J].

Darnell, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) :6221-6224

[27] Turning germ cells into stem cells [J].

Donovan, PJ ;

de Miguel, MP .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2003, 13 (05) :463-471

[28] Identification of putative downstream genes of Oct-4 by suppression-subtractive hybridization [J].

Du, ZW ;

Cong, HC ;

Yao, Z .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 282 (03) :701-706

[29] Chimaerism and erythroid marker expression after microinjection of human acute myeloid leukaemia cells into murine blastocysts [J].

Dürr, M ;

Harder, F ;

Merkel, A ;

Bug, G ;

Henschler, R ;

Müller, AM .

ONCOGENE, 2003, 22 (57) :9185-9191

[30] Role of suppressors of cytokine signaling (Socs) in leukemia inhibitory factor (LIF) -dependent embryonic stem cell survival [J].

Duval, D ;

Reinhardt, S ;

Kedinger, C ;

Boeuf, H .

FASEB JOURNAL, 2000, 14 (11) :1577-1584

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