What is precision medicine?

被引：325

作者：

Koenig, Inke R. ^{[1
,2
,3
]}

Fuchs, Oliver ^{[4
,5
,6
]}

Hansen, Gesine ^{[7
,8
,9
]}

von Mutius, Erika ^{[4
,5
]}

Kopp, Matthias V. ^{[2
,10
]}

机构：

[1] Univ Lubeck, Inst Med Biometrie & Stat, Ratzeburgcr Allee 160, D-23562 Lubeck, Germany

[2] German Ctr Cardiovasc Res DZHK, Lubeck, Germany

[3] German Ctr Lung Res DZL, Airway Res Ctr North ARCN, Hannover, Germany

[4] Ludwig Maximilians Univ Munchen, Dr von Hauner Childrens Hosp, Munich, Germany

[5] German Ctr Lung Res DZL, Comprehens Pneumol Ctr Munich CPC M, Hannover, Germany

[6] Univ Bern, Univ Childrens Hosp Bern, Inselspital, Dept Paediat Resp Med, Bern, Switzerland

[7] Hannover Med Sch, Dept Paediat Pneumol Allergol & Neonatol, Hannover, Germany

[8] Biomed Res Endstage & Obstruct Lung Dis Hannover, Hannover, Germany

[9] German Ctr Lung Res DZL, Hannover, Germany

[10] Univ Lubeck, Dept Paediat Allergy & Pulmonol, Clin Paediat UKSH, Lubeck, Germany

来源：

EUROPEAN RESPIRATORY JOURNAL | 2017年 / 50卷 / 04期

关键词：

VARIABLE SELECTION; GENE-EXPRESSION; ASTHMA; MODEL; VALIDATION; CHILDHOOD; SYSTEMS; EXACERBATIONS; BENRALIZUMAB; ASSOCIATION;

D O I：

10.1183/13993003.00391-2017

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The term "precision medicine" has become very popular over recent years, fuelled by scientific as well as political perspectives. Despite its popularity, its exact meaning, and how it is different from other popular terms such as "stratified medicine", "targeted therapy" or "deep phenotyping" remains unclear. Commonly applied definitions focus on the stratification of patients, sometimes referred to as a novel taxonomy, and this is derived using large-scale data including clinical, lifestyle, genetic and further biomarker information, thus going beyond the classical "signs-and-symptoms" approach. While these aspects are relevant, this description leaves open a number of questions. For example, when does precision medicine begin? In which way does the stratification of patients translate into better healthcare? And can precision medicine be viewed as the end-point of a novel stratification of patients, as implied, or is it rather a greater whole? To clarify this, the aim of this paper is to provide a more comprehensive definition that focuses on precision medicine as a process. It will be shown that this proposed framework incorporates the derivation of novel taxonomies and their role in healthcare as part of the cycle, but also covers related terms.

引用

页数：12

共 88 条

[1] Treatable traits: toward precision medicine of chronic airway diseases [J].